Immunomodulatory effects mediated by serotonin

R Arreola, E Becerril-Villanueva… - Journal of …, 2015 - Wiley Online Library
Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

mRNA expression of serotonin receptors in cells of the immune tissues of the rat

J Stefulj, B Jernej, L Cicin-Sain, I Rinner… - Brain, behavior, and …, 2000 - Elsevier
Serotonin (5-hydroxytryptamine, 5-HT) has been shown to play a role in immunoregulation;
however, little is known about specific subtypes of 5-HT receptors involved in peripheral …

Role of serotonin in the immune system and in neuroimmune interactions

R Mössner, KP Lesch - Brain, behavior, and immunity, 1998 - Elsevier
Serotonin (5-HT) is one of the most extensively studied neurotransmitters of the central
nervous system. 5-HT is, however, also present in a variety of peripheral tissues including in …

Beyond a neurotransmitter: The role of serotonin in inflammation and immunity

H Wu, TH Denna, JN Storkersen, VA Gerriets - Pharmacological research, 2019 - Elsevier
Abstract Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an
important role in peripheral tissues, including the immune system. There is a growing body …

Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor

M León-Ponte, GP Ahern, PJ O'Connell - Blood, 2007 - ashpublications.org
Although typically considered a neurotransmitter, there is substantial evidence that serotonin
(5-HT) plays an important role in the pathogenesis of inflammatory disorders. Despite these …

Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-γ and interleukin-10

M Kubera, G Kenis, E Bosmans, S Scharpé… - …, 2000 - Elsevier
Serotonin (5-HT) is a neurotransmitter and an immune modulator. In vitro, antidepressants
with a serotonergic mode of action have, at concentrations within the therapeutical range …

[HTML][HTML] The effects of serotonin in immune cells

N Herr, C Bode, D Duerschmied - Frontiers in cardiovascular …, 2017 - frontiersin.org
Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a
peripheral hormone. Most of the body's serotonin is circulating in the bloodstream …

[HTML][HTML] Serotonin: a potent immune cell modulator in autoimmune diseases

M Wan, L Ding, D Wang, J Han, P Gao - Frontiers in immunology, 2020 - frontiersin.org
Serotonin, also known as 5-hydroxytryptamine (5-HT) is a signaling mediator that regulates
emotion, behavior, and cognition. Previous studies have focused more on the roles of 5-HT …

The role of serotonin and its receptors in activation of immune responses and inflammation

MS Shajib, WI Khan - Acta physiologica, 2015 - Wiley Online Library
Abstract Serotonin or 5‐hydroxytryptamine (5‐HT) is a neurotransmitter and hormone that
contributes to the regulation of various physiological functions by its actions in the central …

5-HT and the immune system

GP Ahern - Current opinion in pharmacology, 2011 - Elsevier
The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the
central nervous system in immune signaling. Here I review recent studies describing 5-HT …