The mechanobiology theory of the development of medical device-related pressure ulcers revealed through a cell-scale computational modeling framework

A Lustig, R Margi, A Orlov, D Orlova, L Azaria… - … and modeling in …, 2021 - Springer
Pressure ulcers are localized sites of tissue damage which form due to the continuous
exposure of skin and underlying soft tissues to sustained mechanical loading, by …

Membrane permeability during pressure ulcer formation: A computational model of dynamic competition between cytoskeletal damage and repair

NS Jagannathan, L Tucker-Kellogg - Journal of biomechanics, 2016 - Elsevier
Pressure ulcers are debilitating wounds that arise frequently in people who have lost
mobility. Mechanical stress, oxidative stress and ischemia–reperfusion injury are potential …

Pressure ulcers and deep tissue injury: a bioengineering perspective

L Agam, A Gefen - Journal of wound care, 2007 - magonlinelibrary.com
Pressure ulcers are one of the most serious complications in paralysed and immobilised
patients, with severe consequences such as sepsis, osteomyelitis, renal failure and …

Biomechanics of pressure ulcer in body tissues interacting with external forces during locomotion

AFT Mak, M Zhang, EWC Tam - Annual review of biomedical …, 2010 - annualreviews.org
Forces acting on the body via various external surfaces during locomotion are needed to
support the body under gravity, control posture, and overcome inertia. Examples include the …

Linking microvascular collapse to tissue hypoxia in a multiscale model of pressure ulcer initiation

VD Sree, MK Rausch, AB Tepole - Biomechanics and modeling in …, 2019 - Springer
Pressure ulcers are devastating injuries that disproportionately affect the older adult
population. The initiating factor of pressure ulcers is local ischemia, or lack of perfusion at …

[图书][B] Bioengineering research of chronic wounds: a multidisciplinary study approach

A Gefen - 2009 - books.google.com
Pressure-related chronic wounds are an important health concern that affects millions of
patients and accumulates billions in annual costs. These wounds may occur when soft …

A theoretical analysis of damage evolution in skeletal muscle tissue with reference to pressure ulcer development

RGM Breuls, CVC Bouten… - J. Biomech …, 2003 - asmedigitalcollection.asme.org
Soft tissues are sensitive to prolonged compressive loading, eventually leading to tissue
necrosis in the form of pressure ulcers 1. Pressure ulcers can occur in situations where …

Bioengineering models of deep tissue injury

A Gefen - Advances in skin & wound care, 2008 - journals.lww.com
For patients permanently confined to a wheelchair or a bed, pressure ulcers are a major
health risk. Pressure ulcers typically appear in soft tissues enveloping bony prominences …

Bioengineering considerations in the prevention of medical device-related pressure ulcers

DL Bader, PR Worsley, A Gefen - Clinical Biomechanics, 2019 - Elsevier
Background In recent years, it has become increasingly apparent that medical device-
related pressure ulcers represent a significant burden to both patients and healthcare …

Cytoskeleton and plasma-membrane damage resulting from exposure to sustained deformations: a review of the mechanobiology of chronic wounds

A Gefen, D Weihs - Medical engineering & physics, 2016 - Elsevier
The purpose of this review paper is to summarize the current knowledge on cell-scale
mechanically-inflicted deformation-damage, which is at the frontier of cell mechanobiology …