Current indications for cytogenetic evaluation leave the majority of Down syndrome fetuses
undetected. Using advanced maternal age and low maternal serum alpha‐fetoprotein (AFP) …

The use of prenatal ultrasound has proven efficacious for the prenatal diagnosis of
chromosomal abnormalities. The first sonographic sign of Down syndrome, the thickened …

Down syndrome (trisomy 21) is the most common chromosomal abnormality among liveborn
infants in the United States, with an incidence of 1/700 to 1/1000 births. Its incidence rises …

PURPOSE: To evaluate the ability to identify fetuses with autosomal trisomy by use of
sonographic features in the form of a scoring system. MATERIALS AND METHODS: The …

Real‐time and color Doppler ultrasound were used to examine 103 second trimester fetuses
with abnormal chromosomes (trisomies 13, 18, 21 and sex aneuploidy= 86; other= 17) and …

We sought to evaluate the accuracy of the genetic sonogram scoring index in detecting
Down syndrome fetuses in a high‐risk population. Women referred for genetic sonogram …

Sonographic markers for Down's syndrome have been useful in the identification of affected
fetuses. In this study, we evaluated the accuracy of an expanded scoring index that included …

There have been startling advances in the use of ultrasound for the detection of second
trimester fetuses with Down syndrome. In particular, screening programs have begun using …

Second‐trimester sonographic findings of fetal trisomy may include structural abnormalities
or sonographic markers of fetal aneuploidy. Unlike structural anomalies, sonographic …

Objective: This study was undertaken to assess the value of minor ultrasonographic markers
in predicting significant karyotypic abnormalities. Study Design: A total of 2743 fetuses (14 …