Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer
divide, senescent cells remain metabolically active and secrete a plethora of proteins …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …

Cancer is a devastating disease that increases exponentially with age. Cancer arises from
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …

Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response
to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of …

In response to a variety of stresses, mammalian cells undergo a persistent proliferative
arrest known as cellular senescence. Many senescence‐inducing stressors are potentially …

Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought
to be an autonomous tumor-suppressor mechanism. During senescence, cells develop …

In addition to promoting various forms of cell death, most conventional anti-tumor therapies
also promote senescence. There is now extensive evidence that therapy-induced …