TGF-β-induced endothelial to mesenchymal transition in disease and tissue engineering

J Ma, G Sanchez-Duffhues, MJ Goumans… - Frontiers in cell and …, 2020 - frontiersin.org
Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …

Isoform‐specific effects of transforming growth factor β on endothelial‐to‐mesenchymal transition

H Sabbineni, A Verma… - Journal of cellular …, 2018 - Wiley Online Library
Endothelial‐to‐mesenchymal transition (EndMT) was first reported in the embryogenesis.
Recent studies show that EndMT also occurs in the disease progression of atherosclerosis …

TGF-β-induced endothelial-mesenchymal transition in fibrotic diseases

E Pardali, G Sanchez-Duffhues… - International journal of …, 2017 - mdpi.com
Fibrotic diseases are characterized by net accumulation of extracellular matrix proteins in
affected organs leading to their dysfunction and ultimate failure. Myofibroblasts have been …

Fine‐tuning vascular fate during endothelial–mesenchymal transition

L Xiao, AC Dudley - The Journal of pathology, 2017 - Wiley Online Library
In the heart and other organs, endothelial–mesenchymal transition (EndMT) has emerged
as an important developmental process that involves coordinated migration, differentiation …

Regulation of endothelial cell plasticity by TGF-β

LA van Meeteren, P Ten Dijke - Cell and tissue research, 2012 - Springer
Recent evidence has demonstrated that endothelial cells can have a remarkable plasticity.
By a process called Endothelial-to-Mesenchymal Transition (EndMT) endothelial cells …

The therapeutic potential of targeting the endothelial-to-mesenchymal transition

S Man, G Sanchez Duffhues, P Ten Dijke, D Baker - Angiogenesis, 2019 - Springer
Endothelial cells (ECs) have been found to be capable of acquiring a mesenchymal
phenotype through a process known as endothelial-to-mesenchymal transition (EndMT) …

Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases

S Piera-Velazquez, SA Jimenez - Physiological reviews, 2019 - journals.physiology.org
Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

The role of endothelial–mesenchymal transition in development and pathological process

F Lin, N Wang, TC Zhang - IUBMB life, 2012 - Wiley Online Library
Epithelial–mesenchymal transition is an important developmental process, participates in
tumor's formation, invasion, and metastasis and has been extensively studied. Recently …

Endothelial‐to‐mesenchymal transition in cardiovascular diseases: developmental signaling pathways gone awry

G Sánchez‐Duffhues… - Developmental …, 2018 - Wiley Online Library
The process named endothelial‐to‐mesenchymal transition (EndMT) was observed for the
first time during the development of the chicken embryo several decades ago. Of interest …

Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease

Y Yoshimatsu, T Watabe - Inflammation and Regeneration, 2022 - Springer
Abstract Endothelial–mesenchymal transition (EndoMT), a cellular differentiation process in
which endothelial cells (ECs) lose their properties and differentiate into mesenchymal cells …