A novel DNA damage repair gene-related prognostic model for evaluating the prognosis and tumor microenvironment infiltration of esophageal squamous cell …

D Guo, X Zhang, X Du, W Yao, W Shen, S Zhu - BMC Medical Genomics, 2023 - Springer
Background This study aimed to investigate the potential prognostic value of DNA damage
repair genes (DDRGs) in esophageal squamous cell carcinoma (ESCC) and their …

[HTML][HTML] Identification of a prognostic DNA repair gene signature in esophageal cancer

H Du, X Wang, S Xie, A Tartarone… - Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Background DNA repair plays a crucial role in the development and progression of different
types of cancers. Nevertheless, little is known about the role of DNA repair-related genes …

Clinical prognostication and immunotherapy response prediction in esophageal squamous cell carcinoma using the DNA damage repair‐associated signature

P Zhang, B Wen, J Gong, Z Liu, M Zhang… - Environmental …, 2024 - Wiley Online Library
Background The relationship between DNA damage repair (DDR) and cancer is intricately
intertwined; however, its specific role in esophageal squamous cell carcinoma (ESCC) …

DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic …

N Zhao, Z Zhang, Q Wang, L Li, Z Wei, H Chen… - …, 2023 - thelancet.com
Background DNA damage repair (DDR) is a critical process that maintains genomic integrity
and plays essential roles at both the cellular and organismic levels. Here, we aimed to …

Novel DNA damage repair signature for immunotherapy and a proposed molecular subtyping scheme in gastric cancer

X Li, C Wang, H Dong, J Chen, S Chen, M Li, H Chen… - 2024 - researchsquare.com
The DNA damage repair (DDR) mechanisms is closely related to the occurrence and
progression of cancer cells. The diversity and complexity of DNA repair mechanisms also …

A DNA damage repair associated signature for HNSCC

Z Ma, W Liao, S Yang, Y Xu, G Chen, L Song, X Zhang - 2023 - researchsquare.com
Background: DNA damage repair (DDR) genes play a vital role in tumorigenesis and the
tumor microenvironment. However, the specific role of DDR genes in head and neck …

The effects of altered DNA damage repair genes on mutational processes and immune cell infiltration in esophageal squamous cell carcinoma

H Yuan, T Qing, S Zhu, X Yang, W Wu, K Xu… - Cancer …, 2023 - Wiley Online Library
Background Defects in DNA damage repair (DDR) pathways lead to genomic instability and
oncogenesis. DDR deficiency is prevalent in esophageal squamous cell carcinoma (ESCC) …

Identification of DNA-repair-related five-gene signature to predict prognosis in patients with esophageal cancer

L Wang, X Li, L Zhao, L Jiang, X Song, A Qi… - Pathology and …, 2021 - por-journal.com
Esophageal cancer (ESCA) is a leading cause of cancer-related mortality, with poor
prognosis worldwide. DNA damage repair is one of the hallmarks of cancer. Loss of …

[PDF][PDF] Development of a prognostic signature for esophageal cancer based on a novel 7-DNA damage repair genes signature

J Zhan, W Wang, Y Tang, N Zhou, D Jiang - Biocell, 2022 - cdn.techscience.cn
Esophageal cancer (EC) was an aggressive malignant neoplasm characterized by high
morbidity and poor prognosis. Identifying the changes in DNA damage repair genes helps to …

Deleterious alterations of DNA damage response and repair genes and clinical benefit to anti-PD-1 therapy in esophageal squamous cell carcinoma

JC Guo, CC Lin, CL Hsu, TC Huang, HY Kuo, CY Lin… - Esophagus, 2022 - Springer
Background Although DNA damage response and repair (DDR) gene alteration has been
demonstrated as a biomarker for anti-PD-1 therapy in several cancer types, its role in …