Modic changes (MCs) and low back pain are highly correlated and an economic burden to
the society. Previous studies have shown that Cutibacterium acnes (C. acnes) infection can …

Previously, we proposed the hypothesis that similarities in the inflammatory response
observed in acne vulgaris and degenerative disc disease (DDD), especially the central role …

Recently, the role of infection of the intervertebral disc (IVD) with Cutibacterium acnes (C.
acnes) as a contributor to disc-related low back pain (LBP) has been discussed. The aim of …

Background The contribution of Cutibacterium acnes (C. acnes) infection to intervertebral
disc degeneration (IDD) and the antibiotic therapy has evoked several controversies in …

Background: Modic changes (inflammatory-like changes visible on magnetic resonance
imaging [MRI] scans of a vertebral end plate) are common and are associated with low back …

Abstract Purpose Intervertebral disc with Propionibacterium acnes (P. acnes) is suggested to
be an etiology of Modic type I changes in the adjacent bone marrow. However it is unknown …

Lumbar disc degeneration (LDD) and low back pain (LBP) are two conditions that are
closely related. Several studies have shown Cutibacterium acnes colonization of …

Study Design. A case-control study of animal model of Modic changes (MCs) on rabbits.
Objective. To evaluate the feasibility of inducing of MCs by injection of Propionibacterium …

Methods Twelve 6-9-months-old New Zealand white rabbits were used, with procedures
being conducted under the approved Institutional Animal Care and Use Committee (IACUC) …

In the last decade, several studies have demonstrated Cutibacterium acnes colonization in
intervertebral discs (IVDs) in patients with lumbar disc degeneration (LDD) and low back …