Cross-feeding of metabolites between subpopulations can affect cell phenotypes and
population-level behaviors. In chronic Pseudomonas aeruginosa lung infections …

Microbes frequently evolve in reproducible ways. Here, we show that differences in specific
metabolic regulation rather than inter-strain interactions explain the frequent presence of …

Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to
coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of …

Microbes are subjected to selective pressures during chronic infections of host tissues.
Pseudomonas aeruginosa isolates with inactivating mutations in the transcriptional regulator …

Pseudomonas aeruginosa is an opportunistic pathogen that chronically infects the lungs of
individuals with cystic fibrosis (CF) by forming antibiotic-resistant biofilms. Emergence of …

The evolution of bacterial populations during infections can be influenced by various factors
including available nutrients, the immune system, and competing microbes, rendering it …

Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …

Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …

Phenotypic variability among bacteria depends on gene expression in response to different
environments, and it also reflects differences in genomic structure. In this study, we analyzed …

Chronic polymicrobial infections are associated with increased virulence compared to
monospecies infections. However, our understanding of microbial dynamics during …