[HTML][HTML] Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets

F Shu, H Xiao, QN Li, XS Ren, ZG Liu, BW Hu… - … and Targeted Therapy, 2023 - nature.com
Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

[HTML][HTML] Autophagy: an essential degradation program for cellular homeostasis and life

Y Chun, J Kim - Cells, 2018 - mdpi.com
Autophagy is a lysosome-dependent cellular degradation program that responds to a variety
of environmental and cellular stresses. It is an evolutionarily well-conserved and essential …

[HTML][HTML] Biological functions of autophagy genes: a disease perspective

B Levine, G Kroemer - Cell, 2019 - cell.com
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Autophagy in disease: a double-edged sword with therapeutic potential

W Martinet, P Agostinis, B Vanhoecke… - Clinical …, 2009 - portlandpress.com
Autophagy is a catabolic trafficking pathway for bulk destruction and turnover of long-lived
proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy …

Regulation mechanisms and signaling pathways of autophagy

C He, DJ Klionsky - Annual review of genetics, 2009 - annualreviews.org
Autophagy is a process of self-degradation of cellular components in which double-
membrane autophagosomes sequester organelles or portions of cytosol and fuse with …

Transcriptional regulation of autophagy and its implications in human disease

Y Lei, DJ Klionsky - Cell Death & Differentiation, 2023 - nature.com
Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …

Mechanism and medical implications of mammalian autophagy

I Dikic, Z Elazar - Nature reviews Molecular cell biology, 2018 - nature.com
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Autophagy: The spotlight for cellular stress responses

P Ravanan, IF Srikumar, P Talwar - Life sciences, 2017 - Elsevier
Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

[HTML][HTML] Autophagy: a key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators

L Gómez-Virgilio, MC Silva-Lucero, DS Flores-Morelos… - Cells, 2022 - mdpi.com
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …

[HTML][HTML] Why is autophagy important in human diseases?

K Jing, K Lim - Experimental & molecular medicine, 2012 - nature.com
The process of macroautophagy (referred to hereafter as autophagy), is generally
characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past …