[HTML][HTML] Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets
F Shu, H Xiao, QN Li, XS Ren, ZG Liu, BW Hu… - … and Targeted Therapy, 2023 - nature.com
Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …
dynamically degraded and re-processed to maintain physical homeostasis. However, the …
[HTML][HTML] Autophagy: an essential degradation program for cellular homeostasis and life
Y Chun, J Kim - Cells, 2018 - mdpi.com
Autophagy is a lysosome-dependent cellular degradation program that responds to a variety
of environmental and cellular stresses. It is an evolutionarily well-conserved and essential …
of environmental and cellular stresses. It is an evolutionarily well-conserved and essential …
[HTML][HTML] Biological functions of autophagy genes: a disease perspective
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
Autophagy in disease: a double-edged sword with therapeutic potential
W Martinet, P Agostinis, B Vanhoecke… - Clinical …, 2009 - portlandpress.com
Autophagy is a catabolic trafficking pathway for bulk destruction and turnover of long-lived
proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy …
proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy …
Regulation mechanisms and signaling pathways of autophagy
C He, DJ Klionsky - Annual review of genetics, 2009 - annualreviews.org
Autophagy is a process of self-degradation of cellular components in which double-
membrane autophagosomes sequester organelles or portions of cytosol and fuse with …
membrane autophagosomes sequester organelles or portions of cytosol and fuse with …
Transcriptional regulation of autophagy and its implications in human disease
Y Lei, DJ Klionsky - Cell Death & Differentiation, 2023 - nature.com
Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …
Mechanism and medical implications of mammalian autophagy
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …
cellular stress, which prevents cell damage and promotes survival in the event of energy or …
Autophagy: The spotlight for cellular stress responses
Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …
physiological processes including removing of long lived, aggregated and misfolded …
[HTML][HTML] Autophagy: a key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators
L Gómez-Virgilio, MC Silva-Lucero, DS Flores-Morelos… - Cells, 2022 - mdpi.com
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …
[HTML][HTML] Why is autophagy important in human diseases?
The process of macroautophagy (referred to hereafter as autophagy), is generally
characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past …
characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past …