One compelling challenge in the therapy of epilepsy is to develop anti-epileptogenic drugs
with an impact on the disease progression. The search for novel targets has focused …

During the last decade, experimental research has demonstrated a prominent role of glial
cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and …

Background: The lack of treatments which can prevent epilepsy development or improve
disease prognosis represents an unmet and urgent clinical need. The development of such …

Introduction: In the epilepsy therapeutic arena, there is urgent need for developing novel
antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the …

Epilepsy is a brain disease associated with epileptic seizures as well as with
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a …

Epilepsy is one of the most common chronic brain disorders worldwide, affecting 1% of
people across different ages and backgrounds. Epilepsy is defined as the sporadic …

Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

Experimental and clinical evidence have demonstrated the increased synthesis of specific
inflammatory mediators, and the upregulation of their cognate receptors in the chronic …

Accumulating evidence indicates an important pathophysiological role of brain inflammation
in epilepsy. In this review, we will provide an update of specific inflammatory pathways that …

Epilepsy is a common brain disorder characterized by a heterogenous etiology. Its main
features are recurrent seizures. Despite many clinical studies, about 30% of cases are …