In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T
cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three …

CD4+ T cells with cytotoxic activity (CD4 CTL) have been observed in various immune
responses. These cells are characterized by their ability to secrete granzyme B and perforin …

CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …

Research over the past decade has revealed the increasingly complex biologic features of
the CD4+ T-cell lineage. This T-cell subset, which was originally defined on the basis of …

From the textbooks, one can readily learn that CD4+ T-cells display a variety of helper
functions, necessary for the mounting of an efficient adaptive immune response. Indeed, for …

The importance of CD4 T cells in orchestrating the immune system and their role in inducing
effective T cell-mediated therapies for the treatment of patients with select established …

CD8 T cells comprise a powerful branch of the adaptive immune system, yet were not
formally recognized until long after the discovery of antibody. CD8 T cells contribute to the …

T cell immunity is the key to protective immune responses against tumors. Traditionally, this
function has been ascribed to CD8 T lymphocytes with cytotoxic activity, which are restricted …

The two major subsets of peripheral T cells are classically divided into the CD4+ T helper
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …

Abstract In 1986, Mosmann and Coffman identified 2 subsets of activated CD4 T cells, Th1
and Th2 cells, which differed from each other in their pattern of cytokine production and their …