Cancer is one of the life-threatening disorders that, in spite of excellent advances in
medicine and technology, there is no effective cure for. Surgery, chemotherapy, and …

Gastric cancer is highly invasive, aggressively malignant, and amongst the most prevalent of
all forms of cancer. Despite improved management strategies, early stage diagnosis of …

The tumor suppressor gene phosphatase and tensin homolog (PTEN) is essential in
inhibiting tumor growth and metastasis. However, the mechanism by which PTEN restricts …

The incidence of cancer is increasing worldwide, but the biochemical mechanisms for the
occurrence of cancer is not fully understood, and there is no cure for advanced tumors …

Background Abnormality of PTEN gene and Wnt/β-catenin signaling have been strongly
implicated in various malignant cancers. Recently, it has been noted that a functional …

PTENP1 has been demonstrated to function as a tumor suppressor in several cancer cells.
However, its expression and biological roles in gastric cancer (GC) have not yet been …

AIM: To investigate expression of PTEN in gastric cancer and to explore its roles in
tumorigenesis and progression of gastric cancer. METHODS: Formalin-fixed and paraffin …

Phosphorylation of PTEN at residues Ser380/Thr382/383 leads to loss of phosphatase
activity and tumor suppressor function. Here, we found that phosphorylation of PTEN at …

Phosphatase and tensin homolog (PTEN) is a tumour suppressor that represents one of the
most common targets for genetic defect in human cancer. PTEN controls an array of …

PTEN (Phosphatase and tensin homolog deleted on chromosome ten) is a tumor
suppressor that is frequently mutated in most human cancers. PTEN is a lipid and protein …