Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment

Z Zhao, X Xiao, PE Saw, W Wu, H Huang… - Science China Life …, 2020 - Springer
Chimeric antigen receptor (CAR) T cell is a novel approach, which utilizes anti-tumor
immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T …

Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors

BL Zhang, DY Qin, ZM Mo, Y Li, W Wei… - Science China Life …, 2016 - Springer
Recent reports on the impressive efficacy of chimeric antigen receptor (CAR)-modified T
cells against hematologic malignancies have inspired oncologists to extend these efforts for …

Chimeric antigen receptor-immune cells against solid tumors: Structures, mechanisms, recent advances, and future developments

X Li, W Li, L Xu, Y Song - Chinese Medical Journal, 2024 - journals.lww.com
The advent of chimeric antigen receptor (CAR)-T cell immunotherapies has led to
breakthroughs in the treatment of hematological malignancies. However, their success in …

Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

J Li, W Li, K Huang, Y Zhang, G Kupfer… - Journal of hematology & …, 2018 - Springer
Recently, the US Food and Drug Administration (FDA) approved the first chimeric antigen
receptor T cell (CAR-T) therapy for the treatment CD19-positive B cell acute lymphoblastic …

Efficacy, safety, and challenges of CAR T-cells in the treatment of solid tumors

Q Chen, L Lu, W Ma - Cancers, 2022 - mdpi.com
Simple Summary Chimeric antigen receptor T cells (CAR T-cells) are engineered T cells that
target tumor-associated antigens. CAR T-cell therapy is a novel developed immunotherapy …

Obstacles and coping strategies of CAR-T cell immunotherapy in solid tumors

L Miao, Z Zhang, Z Ren, F Tang, Y Li - Frontiers in Immunology, 2021 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell immunotherapy refers to an adoptive
immunotherapy that has rapidly developed in recent years. It is a novel type of treatment that …

New chimeric antigen receptor design for solid tumors

Y Wang, F Luo, J Yang, C Zhao, Y Chu - Frontiers in Immunology, 2017 - frontiersin.org
In recent years, chimeric antigen receptor (CAR) T-cell therapy has become popular in
immunotherapy, particularly after its tremendous success in the treatment of lineage …

Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors

S Han, O Latchoumanin, G Wu, G Zhou, L Hebbard… - Cancer letters, 2017 - Elsevier
Chimeric antigen receptors (CARs) are a series of manufactured receptors that have the
capacity of binding to specific antigens expressed on surface of tumor cells. A CAR normally …

Perspectives on chimeric antigen receptor T-cell immunotherapy for solid tumors

P Kosti, J Maher, JN Arnold - Frontiers in Immunology, 2018 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell therapy entails the genetic engineering of a patient's
T-cells to express membrane spanning fusion receptors with defined specificities for tumor …

Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects

S Di, Z Li - Science China Life Sciences, 2016 - Springer
Chimeric antigen receptors (CARs) are artificial recombinant receptors that generally
combine the antigen-recognition domain of a monoclonal antibody with T cell activation …