Integrative analysis reveals selective 9p24. 1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin …
Classical Hodgkin lymphoma (cHL) and mediastinal large B-cell lymphoma (MLBCL) are
lymphoid malignancies with certain shared clinical, histologic, and molecular features …
lymphoid malignancies with certain shared clinical, histologic, and molecular features …
PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome
MGM Roemer, RH Advani, AH Ligon… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Classical Hodgkin lymphomas (cHLs) include small numbers of malignant Reed-
Sternberg cells within an extensive but ineffective inflammatory/immune cell infiltrate. In cHL …
Sternberg cells within an extensive but ineffective inflammatory/immune cell infiltrate. In cHL …
Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphoma
A Mottok, SS Hung, EA Chavez… - Blood, The Journal …, 2019 - ashpublications.org
Primary mediastinal large B-cell lymphoma (PMBL) represents a clinically and
pathologically distinct subtype of large B-cell lymphomas. Furthermore, molecular studies …
pathologically distinct subtype of large B-cell lymphomas. Furthermore, molecular studies …
PD-L1 gene alterations identify a subset of diffuse large B-cell lymphoma harboring a T-cell–inflamed phenotype
J Godfrey, S Tumuluru, R Bao… - Blood, The Journal …, 2019 - ashpublications.org
Abstract Programmed death-ligand 1 (PD-L1) expression on malignant cells is a dominant
immune escape mechanism across a variety of human cancers. A unique genetic …
immune escape mechanism across a variety of human cancers. A unique genetic …
Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma
C Guiter, I Dusanter-Fourt, C Copie-Bergman… - Blood, 2004 - ashpublications.org
Primary mediastinal large B-cell lymphoma (PMBL), currently recognized as a diffuse large
B-cell lymphoma (DLBCL) subtype, shows increased expression of interleukin 4 (IL-4)/IL-13 …
B-cell lymphoma (DLBCL) subtype, shows increased expression of interleukin 4 (IL-4)/IL-13 …
Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade
Primary mediastinal large B-cell lymphomas (PMBLs) are aggressive tumors that typically
present as large mediastinal masses in young women. PMBLs share clinical, transcriptional …
present as large mediastinal masses in young women. PMBLs share clinical, transcriptional …
Cooperative epigenetic modulation by cancer amplicon genes
Chromosome band 9p24 is frequently amplified in primary mediastinal B cell lymphoma
(PMBL) and Hodgkin lymphoma (HL). To identify oncogenes in this amplicon, we screened …
(PMBL) and Hodgkin lymphoma (HL). To identify oncogenes in this amplicon, we screened …
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin …
Mediastinal large B-cell lymphoma (MLBCL) is a recently identified subtype of diffuse large
B-cell lymphoma (DLBCL) that characteristically presents as localized tumors in young …
B-cell lymphoma (DLBCL) that characteristically presents as localized tumors in young …
Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: implications for …
KR Calvo, A Traverse-Glehen… - Advances in anatomic …, 2004 - journals.lww.com
Expanding on prior studies that have used molecular profiling to elucidate the heterogeneity
of diffuse large B-cell lymphomas (DLBCLs), two recent studies (Rosenwald et al and …
of diffuse large B-cell lymphomas (DLBCLs), two recent studies (Rosenwald et al and …
NFκB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes
F Feuerhake, JL Kutok, S Monti, W Chen, AS LaCasce… - Blood, 2005 - ashpublications.org
Primary mediastinal large B-cell lymphoma (MLBCL) shares important clinical and
molecular features with classic Hodgkin lymphoma, including nuclear localization of the …
molecular features with classic Hodgkin lymphoma, including nuclear localization of the …