Oxidative stress triggered by apigenin induces apoptosis in a comprehensive panel of human cervical cancer‐derived cell lines

RP Souza, PS Bonfim-Mendonca… - Oxidative medicine …, 2017 - Wiley Online Library
Recently, the cytotoxic effects of apigenin (4′, 5, 7‐trihydroxyflavone), particularly its
marked inhibition of cancer cell viability both in vitro and in vivo, have attracted the attention …

Apigenin induces apoptosis via tumor necrosis factor receptor-and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to …

LP Chan, TH Chou, HY Ding, PR Chen… - … et Biophysica Acta (BBA …, 2012 - Elsevier
BACKGROUND: Apigenin, a natural plant flavone, may have chemopreventive and
therapeutic potentials for anti-inflammatory, antioxidant, and anti-cancer. Nevertheless, the …

Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells

PW Zheng, LC Chiang, CC Lin - Life sciences, 2005 - Elsevier
Apigenin is a widely distributed plant flavonoid and was proposed as an antitumor agent. In
this study, we reported for the first time that apigenin inhibited the growth of human cervical …

[HTML][HTML] Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells

Y Qi, Z Ding, Y Yao, F Ren, M Yin… - Experimental and …, 2020 - spandidos-publications.com
Ovarian cancer (OC) is one of the prominent causes of mortality in female patients
diagnosed with gynecologic malignancies. While it has previously been demonstrated that …

[HTML][HTML] Anticancer effects and molecular mechanisms of apigenin in cervical cancer cells

YH Chen, JX Wu, SF Yang, CK Yang, TH Chen… - Cancers, 2022 - mdpi.com
Simple Summary The present study investigated the anticancer effects and molecular
mechanisms of apigenin in cervical cancer in vitro and in vivo. HeLa and C33A cells were …

[HTML][HTML] Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

B Wang, XH Zhao - Oncology reports, 2017 - … .spandidos-publications.com
Apigenin is one of the plant-originated flavones with anticancer activities. In this study,
apigenin was assessed for its in vitro effects on a human colon carcinoma line (HCT‑116 …

Apigenin induces ROS‐dependent apoptosis and ER stress in human endometriosis cells

S Park, W Lim, FW Bazer, G Song - Journal of cellular …, 2018 - Wiley Online Library
Apigenin is a plant‐derived flavonoid having antiproliferative, anti‐inflammatory, and anti‐
angiogenic properties in chronic and metabolic diseases, and cancers. However, the …

[HTML][HTML] Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM

JS Woo, GS Choo, ES Yoo… - Molecular …, 2020 - spandidos-publications.com
Apigenin, an aromatic compound, exhibits antioxidant, anti‑inflammatory and anti‑viral
effects. The present study aimed to investigate the effects of apigenin on cell proliferation …

Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells

I Vrhovac Madunić, J Madunić, M Antunović… - Naunyn-Schmiedeberg's …, 2018 - Springer
Apigenin is found in several dietary plant foods such as vegetables and fruits. To investigate
potential anticancer properties of apigenin on human breast cancer, ER-positive MCF-7 and …

[HTML][HTML] Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis

MD Shi, CK Shiao, YC Lee, YW Shih - Cancer cell international, 2015 - Springer
Background Apigenin is a nontoxic dietary flavonoid, and it may have chemopreventive and
therapeutic potential as an anti-inflammatory, antioxidant, and anti-cancer agent. However …