Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1
N Tuikue Ndam, A Moussiliou… - The Journal of …, 2017 - academic.oup.com
Background. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates
the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues …
the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues …
The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum …
By attaching infected erythrocytes to the vascular lining, Plasmodium falciparum parasites
leave blood circulation and avoid splenic clearance. This sequestration is central to …
leave blood circulation and avoid splenic clearance. This sequestration is central to …
Interaction between endothelial protein C receptor and intercellular adhesion molecule 1 to mediate binding of Plasmodium falciparum-infected erythrocytes to …
ABSTRACT Intercellular adhesion molecule 1 (ICAM-1) and the endothelial protein C
receptor (EPCR) are candidate receptors for the deadly complication cerebral malaria …
receptor (EPCR) are candidate receptors for the deadly complication cerebral malaria …
Acquisition of Antibodies Against Endothelial Protein C Receptor–Binding Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with …
JS Rambhatla, L Turner, L Manning… - The Journal of …, 2019 - academic.oup.com
Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates
parasite sequestration in postcapillary venules in P. falciparum malaria. PfEMP1 types can …
parasite sequestration in postcapillary venules in P. falciparum malaria. PfEMP1 types can …
Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria
F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
Acquisition of IgG to ICAM-1-binding DBLβ domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between groups A, B, and C
RW Olsen, G Ecklu-Mensah, A Bengtsson… - Infection and …, 2019 - Am Soc Microbiol
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria
virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM …
virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM …
[HTML][HTML] Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding
F Lennartz, A Bengtsson, RW Olsen… - The journal of …, 2015 - journals.aai.org
The virulence of Plasmodium falciparum is linked to the ability of infected erythrocytes (IE) to
adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane …
adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane …
Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function
Y Azasi, G Lindergard, A Ghumra… - Proceedings of the …, 2018 - National Acad Sciences
Recent advances have identified a new paradigm for cerebral malaria pathogenesis in
which endothelial protein C receptor (EPCR) is a major host receptor for sequestration of …
which endothelial protein C receptor (EPCR) is a major host receptor for sequestration of …
Cytoadherence phenotype of Plasmodium falciparum- infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral …
Abstract Background Cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs)
in deep microvasculature endothelia plays a major role in the pathogenesis of cerebral …
in deep microvasculature endothelia plays a major role in the pathogenesis of cerebral …
[HTML][HTML] A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies
A Bengtsson, L Joergensen, TS Rask… - The Journal of …, 2013 - journals.aai.org
Cerebral Plasmodium falciparum malaria is characterized by adhesion of infected
erythrocytes (IEs) to the cerebral microvasculature. This has been linked to parasites …
erythrocytes (IEs) to the cerebral microvasculature. This has been linked to parasites …
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