Abstract Background Oxidative stress (OxS) and mitochondrial dysfunction are implicated as
causative factors for aging. Older adults (OAs) have an increased prevalence of elevated …

Abstract Background Elevated oxidative stress (OxS), mitochondrial dysfunction, and
hallmarks of aging are identified as key contributors to aging, but improving/reversing these …

Determinants of length of life are not well understood, and therefore increasing lifespan is a
challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial …

Aging is associated with impaired fasted oxidation of nonesterified fatty acids (NEFA)
suggesting a mitochondrial defect. Aging is also associated with deficiency of glutathione …

Background: Aging is associated with oxidative stress, but underlying mechanisms remain
poorly understood. Objective: We tested whether glutathione deficiency occurs because of …

Restricted dietary intakes of protein or essential amino acids tend to slow aging and boost
lifespan in rodents, presumably because they downregulate IGF-I/Akt/mTORC1 signaling …

Patients with type 2 diabetes (T2D) are known to have mitochondrial dysfunction and
increased insulin resistance (IR), but the underlying mechanisms are not well understood …

Background: Glutathione is a key scavenging antioxidant that opposes the proinflammatory
signaling of hydrogen peroxide. Boosting cellular glutathione levels may have broad utility in …

Glycine is most important and simple, nonessential amino acid in humans, animals, and
many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and …

Significance: A decline in both cognitive and motor functions is one of the characteristics of
aging. This results in changes in learning and memory, as well as deficits in balance and …