Adenosine is a ubiquitous, endogenous purine involved in a variety of physiological and
pathophysiological regulatory mechanisms. Adenosine has been proposed as an …

Adenosine was identified in 1929 and immediately recognised as having a potential role in
therapy for arrhythmia because of its negative chronotropic and dromotropic effects …

Adenosine produces acute inhibition of sinus node and atrioventricular (AV) nodal function.
This profound but short lived electrophysiologic effect makes adenosine a suitable agent for …

Introduction n their classical paper published more than six decades ago, Drury and Szent-
Gyorgyi showed for the first time I that extracellular adenosine and related compounds exert …

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Until quite recently, the cardiodepressant actions of adenosine were widely accepted. A
nucleoside that produces negative chronotropic and ionotropic effects, adenosine, has been …

Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its
membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during …

Adenosine has often been cited as a universal “retaliatory metabolite” against the
destructive cellular mechanisms that are initiated during metabolic/oxidative stress. Despite …

Adenosine is a well-known purine nucleoside with a wide range of cellular and molecular
functions; it is primarily generated by breakdown of adenosine 5′ triphosphate (ATP) …

Adenosine is an endogenous nucleoside that has potent antiarrhythmic effects on
paroxysmal supraventricular tachycardia (PSVT) due to its negative dromotropic effects on …