The response to exogenous pathogens leads to activation of innate immunity through the
release of pathogen-associated molecular patterns (PAMPs) and their binding to pattern …

Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

Why does renal inflammation appear among many of the so-called noninflammatory kidney
diseases? Toll-like receptor research provides a surprising answer because activation of the …

In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Dendritic cells (DCs) are potent antigen-presenting cells critical in regulating the adaptive
immune response. The role of DCs is dichotomous; they may both present antigens and the …

Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the
host to microbial infection and is the leading cause of death in intensive care units. The …

Cellular components released into the external milieu as a result of cell death and sensed
by the body are generally termed damage-associated molecular patterns (DAMPs) …

The list of signals sent by an injured organ to systemic circulation, so-called danger signals,
is growing to include multiple metabolites and secreted moieties, thus revealing a highly …