Organism aging is characterized by increased inflammation and decreased stem cell
function, yet the relationship between these factors remains incompletely understood. This …

All vertebrate blood cells descend from multipotent hematopoietic stem cells (HSCs), whose
activity and differentiation depend on a complex and incompletely understood relationship …

Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system
following injury, such as following infection or inflammation. These challenges impair HSC …

To gain insights into the regulatory mechanisms of hematopoietic stem cells (HSCs), we
employed a genome-wide RNAi screen in human cord-blood derived cells and identified …

The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically
important for proper sister chromatid separation during mitosis. Mutations in the cohesin …

Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Inflammation coordinates tissue regeneration via damaged cell removal and stem cell
activation. Hematopoietic stem cells (HSCs) survive inflammatory stress that kills other blood …

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages.
The functioning of aged HSCs is impaired, including a declined repopulation capacity and …

With a growing aged population, there is an imminent need to develop new therapeutic
strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis …

Aging impairs the regenerative potential of hematopoietic stem cells (HSC) and skews
differentiation towards the myeloid lineage. The bone marrow (BM) microenvironment has …