Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

Inflammation plays a crucial role in the pathophysiology of myocardial infarction (MI). In
particular, reperfusion caused by increased thrombolytic activity or revascularization therapy …

Acute myocardial infarction (AMI) initiates an intense inflammatory response that promotes
cardiac dysfunction, cell death, and ventricular remodeling. The molecular events underlying …

Background Successful reperfusion is the most effective strategy to reduce ischemic injury in
acute myocardial infarction (AMI). Ischemic injury, however, also triggers a secondary …

Significance: An inflammatory response follows an injury of any nature, and while such a
response is an attempt to promote healing, it may, itself, result in further injury. Recent …

Background—Inflammation plays a key role in the pathophysiology of myocardial
ischemia/reperfusion (I/R) injury; however, the mechanism by which myocardial I/R induces …

The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

Acute myocardial infarction (AMI) is associated with the induction of a sterile inflammatory
response that leads to further injury. The NACHT, leucine-rich repeat, and pyrin domain …

Background: Sterile inflammation resulting from myocardial injury activates the NLRP3
inflammasome and amplifies the inflammatory response mediating further damage …

While ischemia itself can kill heart muscle, much of the infarction after a transient period of
coronary artery occlusion has been found to result from injury during reperfusion. Here we …