[HTML][HTML] Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

AJ Dicker, ML Crichton, EG Pumphrey… - Journal of Allergy and …, 2018 - Elsevier
Background Neutrophil extracellular traps (NETs) have been observed in the airway in
patients with chronic obstructive pulmonary disease (COPD), but their clinical and …

Neutrophil extracellular trap (NET) formation characterises stable and exacerbated COPD and correlates with airflow limitation

F Grabcanovic-Musija, A Obermayer, W Stoiber… - Respiratory …, 2015 - Springer
Background COPD is a progressive disease of the airways that is characterized by
neutrophilic inflammation, a condition known to promote the excessive formation of …

Neutrophil extracellular traps are associated with inflammation in chronic airway disease

TK Wright, PG Gibson, JL Simpson, VM McDonald… - …, 2016 - Wiley Online Library
Background and objective Neutrophil extracellular traps (NETs) are web‐like structures
comprising DNA and antimicrobial proteins, expelled from neutrophils during NET osis …

Neutrophil extracellular traps in chronic lung disease: implications for pathogenesis and therapy

HR Keir, JD Chalmers - European Respiratory Review, 2022 - Eur Respiratory Soc
Neutrophilic inflammation has a key role in the pathophysiology of multiple chronic lung
diseases. The formation of neutrophil extracellular traps (NETs) has emerged as a key …

[HTML][HTML] Neutrophil extracellular trap formation and extracellular DNA in sputum of stable COPD patients

F Pedersen, S Marwitz, O Holz, A Kirsten, T Bahmer… - Respiratory …, 2015 - Elsevier
Introduction Chronic obstructive pulmonary disease (COPD) is characterized by neutrophilic
airway inflammation. Neutrophil extracellular trap (NET) formation–a meshwork of neutrophil …

NETopathic inflammation in chronic obstructive pulmonary disease and severe asthma

M Uddin, H Watz, A Malmgren, F Pedersen - Frontiers in immunology, 2019 - frontiersin.org
Neutrophils play a central role in innate immunity, inflammation, and resolution. Unresolving
neutrophilia features as a disrupted inflammatory process in the airways of patients with …

Orchestration of neutrophil extracellular traps (Nets), a unique innate immune function during chronic obstructive pulmonary disease (COPD) development

A Trivedi, MA Khan, G Bade, A Talwar - Biomedicines, 2021 - mdpi.com
Morbidity, mortality and economic burden caused by chronic obstructive pulmonary disease
(COPD) is a significant global concern. Surprisingly, COPD is already the third leading …

Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia

KM Hudock, MS Collins, M Imbrogno… - … of Physiology-Lung …, 2020 - journals.physiology.org
Neutrophil extracellular traps (NETs) provide host defense but can contribute to the
pathobiology of diverse human diseases. We sought to determine the extent and …

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study

HR Keir, A Shoemark, AJ Dicker, L Perea… - The lancet Respiratory …, 2021 - thelancet.com
Background Bronchiectasis is predominantly a neutrophilic inflammatory disease. There are
no established therapies that directly target neutrophilic inflammation because little is …

Neutrophil extracellular traps in airway diseases: Pathological roles and therapeutic implications

A Jo, DW Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophils are important effector cells of the innate immune response that fight pathogens
by phagocytosis and degranulation. Neutrophil extracellular traps (NETs) are released into …