Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms

C O'Gorman, R Lucas, B Taylor - International journal of molecular …, 2012 - mdpi.com
Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system
commonly affecting young adults. Pathologically, there are patches of inflammation …

Environmental factors in multiple sclerosis: epstein‐Barr virus, vitamin D, and cigarette smoking

DM Wingerchuk - Mount Sinai Journal of Medicine: A Journal …, 2011 - Wiley Online Library
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system.
Although its cause is not known, genetic and environmental factors both influence …

Role of environmental factors in multiple sclerosis

A Zarghami, Y Li, SB Claflin, I van der Mei… - Expert Review of …, 2021 - Taylor & Francis
Introduction Environmental factors play a significant role in the pathogenesis and
progression of multiple sclerosis (MS), either acting alone or by interacting with other …

The initiation and prevention of multiple sclerosis

A Ascherio, KL Munger, JD Lünemann - Nature Reviews Neurology, 2012 - nature.com
Although strong genetic determinants of multiple sclerosis (MS) exist, the findings of
migration studies support a role for environmental factors in this disease. Through rigorous …

Environmental risk factors for multiple sclerosis. Part I: the role of infection

A Ascherio, KL Munger - Annals of neurology, 2007 - Wiley Online Library
Although genetic susceptibility explains the clustering of multiple sclerosis (MS) cases within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

The interaction between viral and environmental risk factors in the pathogenesis of multiple sclerosis

RE Tarlinton, T Khaibullin, E Granatov… - International journal of …, 2019 - mdpi.com
Multiple sclerosis (MS) is a chronic debilitating inflammatory disease of unknown ethology
targeting the central nervous system (CNS). MS has a polysymptomatic onset and is usually …

Environmental factors and their timing in adult-onset multiple sclerosis

AE Handel, G Giovannoni, GC Ebers… - Nature Reviews …, 2010 - nature.com
Multiple sclerosis (MS) is a common, complex neurological disease. Epidemiological data
implicate both genetic and environmental factors in the etiology of MS, with various factors …

Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop

MP Amato, T Derfuss, B Hemmer… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Multiple sclerosis (MS) is an inflammatory and neurodegenerative demyelinating disease of
the central nervous system (CNS), most likely autoimmune in origin, usually beginning in …

Environmental factors and their regulation of immunity in multiple sclerosis

MW Koch, LM Metz, SM Agrawal, VW Yong - Journal of the neurological …, 2013 - Elsevier
Epidemiological and clinical studies have shown that environmental factors such as
infections, smoking and vitamin D are associated with the risk of developing multiple …

Environmental risk factors in multiple sclerosis

M Pugliatti, HF Harbo, T Holmøy… - Acta Neurologica …, 2008 - Wiley Online Library
Objectives–Multiple sclerosis (MS) likely results from an interaction between genetic and
exogenous factors. While genetics shapes the overall population MS susceptibility …