[HTML][HTML] Insight into the role of the PI3K/Akt pathway in ischemic injury and post-infarct left ventricular remodeling in normal and diabetic heart
B Walkowski, M Kleibert, M Majka, M Wojciechowska - Cells, 2022 - mdpi.com
Despite the significant decline in mortality, cardiovascular diseases are still the leading
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …
[HTML][HTML] Interplay between PI3K/AKT pathway and heart disorders
S Ghafouri-Fard, A Khanbabapour Sasi… - Molecular biology …, 2022 - Springer
Abstract The PI3K/AKT signaling has crucial role in the regulation of numerous physiological
functions through activation of downstream effectors and modulation of cell cycle transition …
functions through activation of downstream effectors and modulation of cell cycle transition …
[HTML][HTML] Enhanced phosphoinositide 3-kinase (p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes
RH Ritchie, JE Love, K Huynh, BC Bernardo… - Diabetologia, 2012 - Springer
Aims/hypothesis Diabetic cardiomyopathy is characterised by diastolic dysfunction, oxidative
stress, fibrosis, apoptosis and pathological cardiomyocyte hypertrophy. Phosphoinositide 3 …
stress, fibrosis, apoptosis and pathological cardiomyocyte hypertrophy. Phosphoinositide 3 …
The role of PI3K/AKT signaling pathway in myocardial ischemia-reperfusion injury
R Deng, J Zhou - International Immunopharmacology, 2023 - Elsevier
Myocardial ischemia has a high incidence and mortality rate, and reperfusion is currently the
standard intervention. However, reperfusion may lead to further myocardial damage, known …
standard intervention. However, reperfusion may lead to further myocardial damage, known …
[HTML][HTML] PI3Kγ protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway
BJ Haubner, GG Neely, JGJ Voelkl, F Damilano… - PloS one, 2010 - journals.plos.org
Background PI3Kγ functions in the immune compartment to promote inflammation in
response to G-protein-coupled receptor (GPCR) agonists and PI3Kγ also acts within the …
response to G-protein-coupled receptor (GPCR) agonists and PI3Kγ also acts within the …
[HTML][HTML] PI3Kinases in diabetes mellitus and its related complications
A Maffei, G Lembo, D Carnevale - International journal of molecular …, 2018 - mdpi.com
Recent studies have shown that phosphoinositide 3-kinases (PI3Ks) have become the target
of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play …
of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play …
[HTML][HTML] The role of PI3Kα isoform in cardioprotection
X Rossello, JA Riquelme, Z He, S Taferner… - Basic research in …, 2017 - Springer
Ischemic preconditioning (IPC) limits myocardial infarct size through the activation of the
PI3K–Akt signal cascade; however, little is known about the roles of individual PI3K isoforms …
PI3K–Akt signal cascade; however, little is known about the roles of individual PI3K isoforms …
Involvement of phosphoinositide 3-kinase γ in angiogenesis and healing of experimental myocardial infarction in mice
Rationale: Phosphoinositide 3-kinase (PI3K) γ is expressed in hematopoietic cells,
endothelial cells (ECs), and cardiomyocytes and regulates different cellular functions …
endothelial cells (ECs), and cardiomyocytes and regulates different cellular functions …
Angiotensin II Type 1 Receptor–Mediated Upregulation of Calcineurin Activity Underlies Impairment of Cardioprotective Signaling in Diabetic Hearts
H Hotta, T Miura, T Miki, N Togashi, T Maeda… - Circulation …, 2010 - Am Heart Assoc
Rationale: The diabetic heart is resistant to ischemic preconditioning because of diabetes-
associated impairment of phosphatidylinositol 3-kinase (PI3K)-Akt signaling. The …
associated impairment of phosphatidylinositol 3-kinase (PI3K)-Akt signaling. The …
Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic …
Phosphoinositide 3-kinase [PI3K (p110α)] is able to negatively regulate the diabetes-
induced increase in NADPH oxidase in the heart. Patients affected by diabetes exhibit …
induced increase in NADPH oxidase in the heart. Patients affected by diabetes exhibit …