Mitogen-activated protein kinase (MAPK) signal transduction, as a highly conserved
signaling pathway, is reported to be involved in various biological events, including …

The ERK/MAPK cascade is one the four distinctive MAPK cascades which transmit
extracellular signals to intracellular targets. This cascade has an important role in the …

Abstract Phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway is one of the most important proliferative signaling pathways with critical …

Advanced studies of microRNAs (miRNAs) have revealed their manifold biological functions,
including control of cell proliferation, cell cycle and cell death. However, it seems that their …

Abstract The PI3K/AKT pathway is an intracellular signaling pathway with an indispensable
impact on cell cycle control. This pathway is functionally related with cell proliferation, cell …

Colorectal cancer (CRC) is the leading cause of cancer death worldwide. Dysregulation of
RAS/MAPK signaling axis is frequently found in CRC patients. The RAS/MAPK axis …

The highly conserved RAS-mitogen activated protein kinase (MAPK) signaling pathway is
involved in a wide range of cellular processes including differentiation, proliferation, and …

Dysregulated metabolism is a common feature of cancer cells and is considered a hallmark
of cancer. Altered tumor-metabolism confers an adaptive advantage to cancer cells to fulfill …

The major goal of cancer therapy is to destroy cancer cells without harming normal cells.
However, because cancer cells have incredible heterogeneity and adaptability, it is difficult …

Chronic myeloid leukemia (CML) is a severe problem throughout the world and requires
identification of novel targets for its treatment. This multifactorial disease accounts for about …