The high density structure of cartilage matrix negative charge seriously hinders the
penetration and enrichment of drugs/genes into cartilage tissue. In this study …

Sustained and controllable local gene therapy is a potential method for treating osteoarthritis
(OA) through the delivery of therapeutic microRNAs (miRNAs) to targeted cells. However …

Clinically, intra-articular administration can hardly achieve the truly targeted therapy, and the
drugs are usually insufficient to show local and long-term therapeutic effects because of their …

Stem cell tissue engineering is a potential treatment for osteoarthritis. However, the number
of stem cells that can be delivered, loss of stem cells during injection, and migration ability of …

Owing to the lack of blood vessels, nerves, and lymph, articular cartilage defect is difficult to
self‐repair. Although several cartilage tissue engineering products have been authorized for …

Regulating macrophage activation precisely is crucial in treating chronic inflammation in
osteoarthritis (OA). However, the stable pro-inflammatory state and deep distribution of …

The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication
property of the joint, where a progressive and irreversible damage of the articular cartilage …

The differentiation potentials and viability of stem cells are often impaired during cell
isolation and delivery. Inspired by the phenomenon where islands can recruit seabirds for …

The dense structure and the high‐density negative charge of the cartilage matrix impede
drug penetration into the cartilage. Effectively breaking through these barriers and …

In this paper, a novel bioinspired stem cell‐laden microgel and related in vivo cartilage
repair strategy are proposed. In particular, herein the preparation of new stem cell‐laden …