Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery

T Ren, Y Mi, J Wei, X Han, X Zhang, Q Zhu, T Yue… - Molecules, 2024 - mdpi.com
Thrombotic disease has been listed as the third most fatal vascular disease in the world.
After decades of development, clinical thrombolytic drugs still cannot avoid the occurrence of …

Application of nanotechnology in thrombus therapy

K Liao, Q Wu, Y Li, C Wu, Y Zhou… - Journal of Materials …, 2023 - pubs.rsc.org
The diseases caused by two pathological processes, thrombosis, and thromboembolism,
are clinically known as thrombotic diseases, which seriously threaten human life and health …

Application of nanotechnology in thrombus therapy

S Zhou, W Zhao, J Hu, C Mao… - Advanced Healthcare …, 2023 - Wiley Online Library
A thrombus is a blood clot that forms in the lumen of an artery or vein, restricting blood flow
and causing clinical symptoms. Thrombosis is associated with many life‐threatening …

Progress of nanomaterials in the treatment of thrombus

Y Shen, Y Yu, X Zhang, B Hu, N Wang - Drug Delivery and Translational …, 2024 - Springer
Thrombus has long been the major contributor of death and disability because it can cause
adverse effects to varying degrees on the body, resulting in vascular blockage, embolism …

Thrombus-targeting polymeric nanocarriers and their biomedical applications in thrombolytic therapy

Q Guan, H Dou - Frontiers in physiology, 2021 - frontiersin.org
Due to the high morbidity and mortality of cardiovascular diseases, there is an urgent need
for research on antithrombotic strategies. In view of the short half-life, insufficient drug …

Nanomedicine progress in thrombolytic therapy

A Zenych, L Fournier, C Chauvierre - Biomaterials, 2020 - Elsevier
Thrombotic occlusions of blood vessels are responsible for life-threatening cardiovascular
disorders such as myocardial infarction, ischemic stroke, and venous thromboembolism …

[HTML][HTML] Recent strategies on targeted delivery of thrombolytics

T Huang, N Li, J Gao - Asian journal of pharmaceutical sciences, 2019 - Elsevier
Thrombus formed in blood vessel is a progressive process, which would lead to life-
threatening thrombotic diseases such as ischemic stroke. Unlike other diseases, the …

Nanomedicine as a strategy to fight thrombotic diseases

M Varna, M Juenet, R Bayles, M Mazighi… - Future Science …, 2015 - Taylor & Francis
This review highlights the preclinical and clinical research based on the use of nano-and
micro-carriers in thrombolytic drug delivery. Ischemic heart and stroke caused by thrombosis …

Controllable Thrombolysis Using a Nanobubble-Imaging-Guided rtPA Targeted Delivery Strategy

J Tang, H Xu, M Li, Y Liu, F Yang - BME frontiers, 2024 - spj.science.org
Objective: The objective of this work is to design and fabricate a novel multifunctional
nanocarrier combining thrombus-targeted imaging and ultrasound-mediated drug delivery …

Long-circulating nanoparticles as passive targeting nanocarriers for the treatment of thrombosis

J Li, K Lu, S Sun, J Peng, L Zhao - Nanoscale, 2024 - pubs.rsc.org
Thrombosis is the major cause of cardiovascular diseases. Only a small subset of patients
could benefit from thrombolytic therapy due to the high bleeding risk brought about by the …