TNF signals via two receptors, TNFR1 and TNFR2, which play contrasting roles in immunity.
Most of the pro-inflammatory effects of TNF are mediated by TNFR1, whereas TNFR2 is …

Tumour necrosis factor-α (TNF-α) is a highly pleiotropic cytokine with effects on multiple
pathological and physiological functions via two distinct receptors, TNFR1 and TNFR2 …

The TNF signaling pathway is a valuable target in the therapy of autoimmune diseases, and
anti-TNF drugs are successfully used to treat diseases such as rheumatoid arthritis, Crohn's …

Introduction: Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the
cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory activities …

Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that signals through two distinct
receptors, TNFR1 and TNFR2. TNF is essentially involved in the pathogenesis of various …

The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2,
and is a central mediator of various immune-mediated diseases. Indeed, TNF-neutralizing …

Anti-TNF biologics have achieved great success in the treatment of autoimmune diseases
and have been the most selling biologics on market. However, the anti-TNF biologics have …

TNF is an essential regulator of the immune system. Dysregulation of TNF plays a role in the
pathology of many auto-immune diseases. TNF-blocking agents have proven successful in …

Tumor necrosis factor (TNF) and its receptors, TNF receptor-1 (TNFR1) and TNFR2, have
received considerable attention in basic and clinical research for more than two decades …

Deregulation of the tumor necrosis factor (TNF) plays an important role in the initiation and
perpetuation of chronic inflammation and has been implicated in the development of various …