Marfan Syndrome (MFS) is a genetic disorder affecting connective tissue. Progression of
MFS leads to changes in aortic stiffness, contributing to aneurysm and dissection; major …

Marfan syndrome (MFS) is a multi-system connective tissue disorder that results from
mutations to the gene that codes the elastin-associated glycoprotein fibrillin-1. Although …

Marfan syndrome (MFS) is a genetic disorder that affects connective tissue, impairing
cardiovascular structures and function, such as heart valves and aorta. Thus, patients with …

Thoracic aortic aneurysms are characterized by a progressive loss of biomechanical
functionality resulting from degenerative changes in wall composition, microstructure, and …

Background Marfan syndrome (MFS), a genetic disorder of the connective tissue, has been
strongly linked to dilation of the thoracic aorta, among other cardiovascular complications …

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1
gene, with aortic aneurysm considered as the most life-threatening complication. Previous …

Marfan Syndrome (MFS) is an autosomal dominant disorder in a family of connective tissue
disorders. It is well established that vascular complications in MFS is associated with …

Aortic root dilation and propensity to dissection are typical manifestations of the Marfan
Syndrome (MS), a genetic defect leading to the degeneration of the elastic fibres. Dilation …

Marfan syndrome (MFS) is an autosomal dominant disease of the connective tissue due to
mutations in the fibrillin-1 gene (FBN1). This study aimed at characterizing microelastic …

Mutations in extracellular matrix and smooth muscle cell contractile proteins predispose to
thoracic aortic aneurysms in Marfan syndrome (MFS) and related disorders. These genetic …