Strain-transcending neutralization of malaria parasite by antibodies against Plasmodium falciparum enolase

S Dutta, A Tewari, C Balaji, R Verma, A Moitra… - Malaria Journal, 2018 - Springer
Background Plasmodium enolase is a target for the growth neutralizing antibodies.
Interestingly, the three invasive stages ie sporozoites, merozoites, and ookinetes express …

Immunogenicity and protective potential of a Plasmodium spp. enolase peptide displayed on archaeal gas vesicle nanoparticles

S Dutta, P DasSarma, S DasSarma, GK Jarori - Malaria journal, 2015 - Springer
Background Plasmodium falciparum enolase has been shown to localize on the surface of
merozoites and ookinetes. Immunization of mice with recombinant Plasmodium enolase …

Plasmodium falciparum enolase: stage-specific expression and sub-cellular localization

I Pal Bhowmick, N Kumar, S Sharma, I Coppens… - Malaria journal, 2009 - Springer
Background In an earlier study, it was observed that the vaccination with Plasmodium
falciparum enolase can confer partial protection against malaria in mice. Evidence has also …

Protective Properties and Surface Localization of Plasmodium falciparum Enolase

I Pal-Bhowmick, M Mehta, I Coppens… - Infection and …, 2007 - Am Soc Microbiol
The enolase protein of the human malarial parasite Plasmodium falciparum has recently
been characterized. Apart from its glycolytic function, enolase has also been shown to …

[PDF][PDF] Generation and characterisation of monoclonal antibodies specific to Plasmodium falciparum enolase

I Pal-Bhowmick, HK Vora, J Roy… - Journal of Vector …, 2006 - researchgate.net
Background & objectives: Glycolysis is the sole source of energy for the intraerythrocytic
stages of Plasmodium falciparum, making glycolytic enzymes putative therapeutic targets …

Surface-expressed enolases of Plasmodium and other pathogens

AK Ghosh, M Jacobs-Lorena - Memorias do Instituto Oswaldo Cruz, 2011 - SciELO Brasil
Enolase is the eighth enzyme in the glycolytic pathway, a reaction that generates ATP from
phosphoenol pyruvate in cytosolic compartments. Enolase is essential, especially for …

EWGWS insert in Plasmodium falciparum ookinete surface enolase is involved in binding of PWWP containing peptides: implications to mosquito midgut invasion by …

D Mukherjee, P Mishra, M Joshi, PK Thakur… - Insect biochemistry and …, 2016 - Elsevier
There are multiple stages in the life cycle of Plasmodium that invade host cells. Molecular
machinery involved is such host–pathogen interactions constitute excellent drug targets …

Effect of deletion of a plant like pentapeptide insert on kinetic, structural and immunological properties of enolase from Plasmodium falciparum

HK Vora, FR Shaik, I Pal-Bhowmick, R Mout… - Archives of biochemistry …, 2009 - Elsevier
Plasmodium falciparum enolase (Pfen) is of photosynthetic lineage as evident from the
presence of a plant like pentapeptide insert 104EWGWS108 in a highly conserved surface …

Sub-cellular localization and post-translational modifications of the Plasmodium yoelii enolase suggest moonlighting functions

I Pal-Bhowmick, HK Vora, GK Jarori - Malaria Journal, 2007 - Springer
Abstract Background Enolase (2-Phospho-D-glycerate hydrolase; EC 4.2. 1.11) is one of the
glycolytic enzymes, whose levels are highly elevated in malaria parasite infected red blood …

Differential susceptibility of Plasmodium falciparum versus yeast and mammalian enolases to dissociation into active monomers

I Pal‐Bhowmick, S Krishnan, GK Jarori - The FEBS Journal, 2007 - Wiley Online Library
In the past, several unsuccessful attempts have been made to dissociate homodimeric
enolases into their active monomeric forms. The main objective of these studies had been to …