The mevalonate–isoprenoid–cholesterol biosynthesis pathway plays a key role in human
health and disease. The importance of this pathway is underscored by the discovery that two …

Two major isoprenoids, farnesyl pyrophosphate and geranylgeranyl pyrophosphate, serve
as lipid donors for the posttranslational modification (known as prenylation) of proteins that …

Isoprenoids are synthesized in all living organisms and are incorporated into diverse
classes of end-products that participate in a multitude of cellular processes relating to cell …

Post-translational modification of small GTPases by farnesyl-(FPP) and
geranylgeranylpyrophosphate (GGPP) has generated much attention due to their potential …

The modification of eukaryotic proteins by isoprenoid lipids, which is known as prenylation,
controls the localization and activity of a range of proteins that have crucial functions in …

Protein prenylation is a post-translational modification that is responsible for membrane
association and protein–protein interactions. The oncogenic protein Ras, which is …

In the human body, the complex biochemical network known as the mevalonate pathway is
responsible for the biosynthesis of all isoprenoids, which consists of a vast array of …

Protein prenylation is an important lipid posttranslational modification of proteins. It includes
protein farnesylation and geranylgeranylation, in which the 15-carbon farnesyl …

Protein post-translational modifications increase the functional diversity of the proteome by
covalently adding chemical moieties onto proteins thereby changing their activation state …

Prenylation consists of the addition of an isoprenoid group to a cysteine residue located
near the carboxyl terminal of a protein. This enzymatic posttranslational modification is …