It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Neurodegenerative diseases represent a significant unmet medical need in our aging
society. There are no effective treatments for most of these diseases, and we know …

Neurodegenerative diseases (NDDs) are a heterogeneous group of diseases that are
characterized by the progressive loss of neurons leading to motor, sensory, and/or cognitive …

Human induced pluripotent stem cells and neurodegenerative d... : Current Opinion in
Neurology Human induced pluripotent stem cells and neurodegenerative disease: prospects for …

The systematic generation of neurons from patients with neurological disorders can provide
important insights into disease pathology, progression and mechanism. This review will …

Alzheimer's disease (AD) is the most common cause of dementia in those over the age of
65. While a numerous of disease-causing genes and risk factors have been identified, the …

Cellular reprogramming of somatic cells to human pluripotent stem cells (iPSC) represents
an efficient tool for in vitro modeling of human brain diseases and provides an innovative …

Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

Adult-onset neurodegenerative diseases are among the most difficult human health
conditions to model for drug development. Most genetic or toxin-induced cell and animal …

Developing efficient models for neurological diseases enables us to uncover disease
mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming …