The liquid antisolvent (LAS) precipitation process for production of ultra-fine particles has
been widely researched for a last few decades. In LAS process, precipitation of solute is …

The objective of this work was to develop a better understanding of a potentially scalable,
liquid antisolvent (LAS) precipitation process, for the preparation of stable aqueous …

Particle formation by the liquid antisolvent (LAS) process involves two steps: mixing of
solution–antisolvent streams to generate supersaturation and precipitation (which includes …

Rapid and homogeneous mixing of the solvent and antisolvent is critical to achieve
submicron drug particles by antisolvent precipitation technique. This work aims to develop a …

Organic itraconazole (ITZ) solutions were mixed with aqueous solutions to precipitate sub-
300 nm particles over a wide range of energy dissipation rates, even for drug loadings as …

Background Nanosuspensions, liquid dispersions with nanometer size distribution, are
becoming trendy in pharmaceutical practice to formulate poorly water-soluble drugs and to …

Nano-sizing offers a promising method for the formulation of poorly aqueous soluble
compounds. Nanosuspensions can be prepared by top-down or bottom-up approaches. The …

Nanoparticle engineering is a well-defined technique employed as a novel and effective
method in drug design and delivery. It is widely used to control particle size, as well as the …

Nanoparticles are a drug delivery platform that can enhance the efficacy of active
pharmaceutical ingredients, including poorly-water soluble compounds, ionic drugs …

This study investigates formulation and process modifications to improve the versatility of the
nanoprecipitation technique, particularly with respect to the encapsulation of hydrophilic …