Sex differences in depression: Insights from clinical and preclinical studies

RS Eid, AR Gobinath, LAM Galea - Progress in neurobiology, 2019 - Elsevier
Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Sex differences in depression and anxiety

P Pavlidi, N Kokras, C Dalla - Sex Differences in Brain Function and …, 2022 - Springer
Depression and anxiety disorders carry a tremendous worldwide burden and emerge as a
significant cause of disability among western societies. Both disorders are known to …

Influence of sex and stress exposure across the lifespan on endophenotypes of depression: focus on behavior, glucocorticoids, and hippocampus

AR Gobinath, R Mahmoud, LAM Galea - Frontiers in neuroscience, 2015 - frontiersin.org
Sex differences exist in vulnerability, symptoms, and treatment of many neuropsychiatric
disorders. In this review, we discuss both preclinical and clinical research that investigates …

Sex differences in depression during pregnancy and the postpartum period

I Sundström Poromaa, E Comasco… - Journal of …, 2017 - Wiley Online Library
Women have a lifetime risk of major depression double that of men but only during their
reproductive years. This sex difference has been attributed partially to activational effects of …

Preclinical sex differences in depression and antidepressant response: Implications for clinical research

N Kokras, C Dalla - Journal of neuroscience research, 2017 - Wiley Online Library
Women suffer from depression and anxiety disorders more often than men, and as a result
they receive antidepressants to a greater extent. Sex differences in antidepressant response …

Sex differences and the neurobiology of affective disorders

DR Rubinow, PJ Schmidt - Neuropsychopharmacology, 2019 - nature.com
Observations of the disproportionate incidence of depression in women compared with men
have long preceded the recent explosion of interest in sex differences. Nonetheless, the …

Large-scale transcriptomics studies provide insight into sex differences in depression

ML Seney, J Glausier, E Sibille - Biological psychiatry, 2022 - Elsevier
Major depressive disorder (MDD) is a leading cause of disability, affecting more than 300
million people worldwide. We first review the well-known sex difference in incidence of …

Why is depression more prevalent in women?

PR Albert - Journal of Psychiatry and Neuroscience, 2015 - jpn.ca
Major depression is a chronic illness with a high prevalence and is a major component of
disease burden. Depressive disorders were the second leading cause of years lived with …

[HTML][HTML] Biological markers of sex-based differences in major depressive disorder and in antidepressant response

RC Silva, C Pisanu, E Maffioletti, V Menesello… - European …, 2023 - Elsevier
Major depressive disorder (MDD) presents different clinical features in women and men,
with women being more affected and responding differently to antidepressant treatment …

Pathophysiological mechanisms implicated in postpartum depression

JL Payne, J Maguire - Frontiers in neuroendocrinology, 2019 - Elsevier
This review aims to summarize the diverse proposed pathophysiological mechanisms
contributing to postpartum depression, highlighting both clinical and basic science research …