Mitochondria and reactive oxygen species in aging and age-related diseases
Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …
Mitochondria‐ros crosstalk in the control of cell death and aging
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …
Oxidative stress, mitochondrial dysfunction, and aging
H Cui, Y Kong, H Zhang - Journal of signal transduction, 2012 - Wiley Online Library
Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …
functions and increase in mortality that is often accompanied by many pathological …
Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging
HC Lee, YH Wei - Biogerontology, 2001 - Springer
Respiratory function decline and increase ofoxidative stress in mitochondria have
beenproposed as important contributors to humanaging. A wide spectrum of alterations in …
beenproposed as important contributors to humanaging. A wide spectrum of alterations in …
Aging hallmarks and the role of oxidative stress
E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …
function of the organism and an increased risk of age-related chronic diseases such as …
Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging
Under normal physiological conditions, reactive oxygen species (ROS) serve as 'redox
messengers' in the regulation of intracellular signalling, whereas excess ROS may induce …
messengers' in the regulation of intracellular signalling, whereas excess ROS may induce …
Mitochondrial management of reactive oxygen species
Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …
formation of harmful species, such as radicals and other reactive oxygen species, known as …
The role of mitochondrial oxidative stress in aging
J Sastre, FV Pallardó, J Viña - Free Radical Biology and Medicine, 2003 - Elsevier
Mitochondria are both a major source of oxidants and a target for their damaging effects,
and, therefore, mitochondrial oxidative stress appears to be a cause, rather than a …
and, therefore, mitochondrial oxidative stress appears to be a cause, rather than a …
Role of mitochondrial reactive oxygen species in homeostasis regulation
B Zhang, C Pan, C Feng, C Yan, Y Yu, Z Chen… - Redox …, 2022 - Taylor & Francis
Mitochondria are the main source of reactive oxygen species (ROS) in cells. Early studies
have shown that mitochondrial reactive oxygen species (mROS) are related to the …
have shown that mitochondrial reactive oxygen species (mROS) are related to the …
Mitochondrial oxidative stress in aging and healthspan
The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …