Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …

Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Respiratory function decline and increase ofoxidative stress in mitochondria have
beenproposed as important contributors to humanaging. A wide spectrum of alterations in …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Under normal physiological conditions, reactive oxygen species (ROS) serve as 'redox
messengers' in the regulation of intracellular signalling, whereas excess ROS may induce …

Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

Mitochondria are both a major source of oxidants and a target for their damaging effects,
and, therefore, mitochondrial oxidative stress appears to be a cause, rather than a …

Mitochondria are the main source of reactive oxygen species (ROS) in cells. Early studies
have shown that mitochondrial reactive oxygen species (mROS) are related to the …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …