Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia
pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic …

Background The synaptic hypothesis is an influential theory of the pathoetiology of
schizophrenia (SCZ), which is supported by the finding that there is lower uptake of the …

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but
this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein …

Decreased synaptic spine density has been the most consistently reported postmortem
finding in schizophrenia (SCZ). A recently developed in vivo measure of synaptic vesicle …

BackgroundRecent post-mortem and magnetic resonance imaging (MRI) studies strongly
suggest a decrease in the volume of the hippocampus and other limbic temporal structures …

Background Magnetic resonance spectroscopy studies measuring brain glutamate
separately from glutamine are helping elucidate schizophrenia pathophysiology. An …

Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

Background: Proton magnetic resonance spectroscopic imaging (1H-MRSI) studies have
reported reductions of N-acetyl aspartate (NAA), a marker of neuronal integrity, in the …

Abstract Changes in brain pathology as schizophrenia progresses have been repeatedly
suggested by previous studies. Meta-analyses of previous proton magnetic resonance …

BACKGROUND: Converging evidence in schizophrenia points to disruption of the dopamine
and glutamate neurotransmitter systems in the pathophysiology of the disorder. Dopamine is …