DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies
Molecular subclassification is rapidly informing the clinical management of
medulloblastoma. However, the disease remains associated with poor outcomes and …
medulloblastoma. However, the disease remains associated with poor outcomes and …
Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation …
Accepted: 4 May 2013/Published online: 14 May 2013© The Author (s) 2013. This article is
published with open access at Springerlink. com are becoming increasingly important, not …
published with open access at Springerlink. com are becoming increasingly important, not …
DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas
A Korshunov, F Sahm, O Zheludkova… - Neuro …, 2019 - academic.oup.com
Background Wingless-activated medulloblastoma (WNT MB) represents a well-
characterized molecular variant accounting for 10–15% of all MB and is associated with a …
characterized molecular variant accounting for 10–15% of all MB and is associated with a …
Prognostic effect of whole chromosomal aberration signatures in standard-risk, non-WNT/non-SHH medulloblastoma: a retrospective, molecular analysis of the HIT …
T Goschzik, EC Schwalbe, D Hicks, A Smith… - The lancet …, 2018 - thelancet.com
Background Most children with medulloblastoma fall within the standard-risk clinical disease
group defined by absence of high-risk features (metastatic disease, large-cell/anaplastic …
group defined by absence of high-risk features (metastatic disease, large-cell/anaplastic …
Advances in the classification of pediatric brain tumors through DNA methylation profiling: from research tool to frontline diagnostic
Despite significant improvements in pediatric brain tumor therapy and outcome, too many
children still die of disease, and too many survivors experience significant sequelae as a …
children still die of disease, and too many survivors experience significant sequelae as a …
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study
Background International consensus recognises four medulloblastoma molecular
subgroups: WNT (MB WNT), SHH (MB SHH), group 3 (MB Grp3), and group 4 (MB Grp4) …
subgroups: WNT (MB WNT), SHH (MB SHH), group 3 (MB Grp3), and group 4 (MB Grp4) …
DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma
Revised: 10 October 2017/Accepted: 10 October 2017/Published online: 13 October 2017©
Springer-Verlag GmbH Germany 2017 very important for patient stratification in a clinical …
Springer-Verlag GmbH Germany 2017 very important for patient stratification in a clinical …
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
Background Medulloblastoma is the most common malignant brain tumor in children.
Despite recent improvements in cure rates, prediction of disease outcome remains a major …
Despite recent improvements in cure rates, prediction of disease outcome remains a major …
Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers
Background Accurate outcome prediction in neuroblastoma, which is necessary to enable
the optimal choice of risk-related therapy, remains a challenge. To improve neuroblastoma …
the optimal choice of risk-related therapy, remains a challenge. To improve neuroblastoma …
Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED …
M Mynarek, D Obrecht, M Sill, D Sturm… - Acta …, 2023 - Springer
Molecular groups of medulloblastoma (MB) are well established. Novel risk stratification
parameters include Group 3/4 (non-WNT/non-SHH) methylation subgroups I–VIII or whole …
parameters include Group 3/4 (non-WNT/non-SHH) methylation subgroups I–VIII or whole …