Klebsiella pneumoniae is the main pathogen of hospital-acquired infections causing acute
pneumonia, which is characterized by drug resistance, virulence and mortality, and for which …

Drug resistance of Klebsiella pneumoniae severely threatens human health. Overcoming
the mechanisms of K. pneumoniae resistance to develop novel vaccines against drug …

The increase in drug-resistant microbial infections and the reduction in the number of
approvals for new antibiotic categories make engineered biological agents difficult to use in …

Infection resulting from carbapenem-resistant Klebsiella pneumoniae (CRKP) is an
intractable clinical problem. Outer membrane vesicles (OMVs) from CRKP are believed to be …

The lack of bacterial-targeting function in antibiotics and their prophylactic usage have
caused overuse of antibiotics, which lead to antibiotic resistance and inevitable long-term …

Pneumococcal infections represent a global health threat, which requires novel vaccine
developments. Extracellular vesicles are secreted from most cells, including prokaryotes …

Tissue bacterial infections are a major pathological factor in many diseases. Effects on this
aspect are in focus for the development of coordinated therapeutic strategies for bacterial …

Bacterial infections cause acute and chronic diseases. Antimicrobial resistance and aging-
related immune weakness remain challenging in therapy of infectious diseases. Vaccines …

Vaccination has become an increasingly attractive strategy for protecting against antibiotic-
resistant infections. Nanovaccines based on the outer membrane from Gram-negative …

The emergence of multidrug-resistant Klebsiella pneumoniae highlights the need to develop
preventive measures to ameliorate Klebsiella infections. Bacteria-derived extracellular …