Aims Basolateral amygdala (BLA), as a center for stress responses and emotional
regulation, is involved in visceral hypersensitivity of irritable bowel syndrome (IBS) induced …

Patients with post-traumatic stress disorder (PTSD) are usually at an increased risk for
chronic disorders, such as irritable bowel syndrome (IBS), characterized by hyperalgesia …

Patients with irritable bowel syndrome (IBS) experience not only enhanced visceral pain but
also emotional comorbidities, such as anxiety and depression. Early life stress (ELS) is a …

Accumulating evidences suggest dysfunctions in the hippocampus are associated with
chronic pain. Nevertheless, the role of hippocampal circuitry in pain memories and …

Stress and anxiety contribute to the pathophysiology of irritable bowel syndrome (IBS), a
female-predominant disorder of the gut-brain axis, characterized by abdominal pain due to …

Abstract Background Ephrin‐B2/EphB receptor signaling contributes to persistent pain
states such as postinflammatory and neuropathic pain. Visceral hypersensitivity (VHS) is a …

Background Long‐term stress was suggested to cause visceral hypersensitivity and promote
functional gastrointestinal disorders (FGIDs). Some brain regions such as the anterior …

The rostral anterior cingulate cortex (rACC) has been found to be an important brain region
in mediating visceral hypersensitivity. However, the underlying mechanisms remain unclear …

Aims Sustained visceral hypersensitivity is a hallmark of irritable bowel syndrome (IBS)
could be partially explained by enteric neural remodeling. Particularly, synaptic plasticity in …

Irritable bowel syndrome (IBS) is characterized by gastrointestinal dysmotility and visceral
hyperalgesia, and the impaired brain–gut axis is accepted as a crucial cause for the onset of …