Pain perception is decreased by shifting attentional focus away from a threatening event.
This attentional analgesia engages parallel descending control pathways from anterior …

Pain demands attention, yet pain can be reduced by focusing attention elsewhere. The
neural processes involved in this robust psychophysical phenomenon, attentional …

Previous human imaging studies manipulating attention or expectancy have identified the
periaqueductal gray (PAG) as a key brainstem structure implicated in endogenous …

Pain perception can be powerfully influenced by an individual's expectations and beliefs.
Although the cortical circuitry responsible for pain modulation has been thoroughly …

The down-regulation of pain through beliefs is commonly discussed as a form of emotion
regulation. In line with this interpretation, the analgesic effect has been shown to co-occur …

The dynamic interaction between ascending spinocortical nociceptive signaling and the
descending control of the dorsal horn (DH) by brain regions such as the periaqueductal gray …

Pain is more than merely nociception and response, but rather it encompasses emotional,
behavioral and cognitive components that make up the pain experience. With the recent …

Patients with neuropathic pain and fibromyalgia showed reduced or absent offset analgesia
(OA) response and attenuated cerebral activity in descending pain modulatory and reward …

Mechanical hyperalgesia is one distressing symptom of neuropathic pain which is explained
by central sensitization of the nociceptive system. This sensitization can be induced …

Opioids are potent analgesic drugs with widespread cortical, subcortical, and spinal targets.
In particular, the central pain system comprising ascending and descending pain pathways …