Therapeutic mechanisms of psychedelics and entactogens

BD Heifets, DE Olson - Neuropsychopharmacology, 2024 - nature.com
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

FX Vollenweider, KH Preller - Nature Reviews Neuroscience, 2020 - nature.com
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

The subjective effects of psychedelics may not be necessary for their enduring therapeutic effects

DE Olson - ACS Pharmacology & Translational Science, 2020 - ACS Publications
Psychedelics represent one of the most promising classes of experimental medicines for the
treatment of neuropsychiatric disorders due to their ability to promote neural plasticity and …

[HTML][HTML] The mechanistic divide in psychedelic neuroscience: An unbridgeable gap?

BR Barksdale, MK Doss, GA Fonzo, CB Nemeroff - Neurotherapeutics, 2024 - Elsevier
In recent years, psychedelics have generated considerable excitement and interest as
potential novel therapeutics for an array of conditions, with the most advanced evidence …

The effects of psychedelics on neuronal physiology

CJ Hatzipantelis, DE Olson - Annual Review of Physiology, 2024 - annualreviews.org
Psychedelics are quite unique among drugs that impact the central nervous system, as a
single administration of a psychedelic can both rapidly alter subjective experience in …

[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

M van Elk, DB Yaden - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Bedside to bench: the outlook for psychedelic research

VP Acero, ES Cribas, KD Browne, O Rivellini… - Frontiers in …, 2023 - frontiersin.org
There has recently been a resurgence of interest in psychedelic compounds based on
studies demonstrating their potential therapeutic applications in treating post-traumatic …

Psychedelics and neural plasticity: therapeutic implications

SF Grieco, E Castrén, GM Knudsen… - Journal of …, 2022 - Soc Neuroscience
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …

A brief historical overview of psychedelic research

MA Geyer - Biological Psychiatry: Cognitive Neuroscience and …, 2023 - Elsevier
Classical serotonergic psychedelics such as lysergic acid diethylamide (LSD) or the
naturally occurring compounds psilocybin and mescaline produce profound changes in …

[HTML][HTML] Psychedelics and neuroplasticity: a systematic review unraveling the biological underpinnings of psychedelics

CMH De Vos, NL Mason, KPC Kuypers - Frontiers in psychiatry, 2021 - frontiersin.org
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …