We developed stable isotope labeling and mass spectrometry approaches to measure the
kinetics of multiple isoforms and fragments of tau in the human central nervous system …

Tau protein aggregation into neurofibrillary tangles in the central nervous system contributes
to the etiology of certain neurodegenerative disorders, including Alzheimer's disease (AD) …

Recent evidence suggests that tau aggregation may spread via extracellular release and
subsequent uptake by synaptically connected neurons, but little is known about the …

In Alzheimer's disease, neurofibrillary tangle pathology appears to spread along neuronal
connections, proposed to be mediated by the release and uptake of abnormal, disease …

Human brain encompasses six tau isoforms, containing either three (3R) or four (4R) repeat
domains, all of which participate in the pathogenesis of human tauopathies. To investigate …

Conditional overexpression of four-repeat human tau containing the P301L missense
mutation in the rTg4510 mouse model of tauopathy leads to progressive accumulation of …

Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and
other tauopathies. High-throughput screening in neurons derived from human induced …

The microtubule-associated protein tau plays a critical role in the pathogenesis of
Alzheimer's disease and several related disorders. In the disease tau aggregates into paired …

Levels of tau in cerebrospinal fluid (CSF) are elevated in Alzheimer's disease (AD) patients.
It is believed this elevation is related to the tau pathology and neurodegeneration observed …

The microtubule-associated protein tau (tau) forms hyperphosphorylated aggregates in the
brains of tauopathy patients that can be pathologically and biochemically defined as distinct …