The long-lasting humoral immunity induced by viral infections or vaccinations depends on
memory B cells with greatly increased affinity to viral antigens, which are evolved from …

Protection against pathogen re-infection is mediated, in large part, by two humoral cellular
compartments, namely, long-lived plasma cells and memory B cells. Recent data have …

Establishment of humoral immune memory depends on two layers of defense: pre-existing
antibodies secreted by long-lived plasma cells; and the antibodies produced by antigen …

The vast majority of vaccines exploit antibody memory to induce lasting immunity. Memory B
cells are generated during the initial response to infection, but persist long after the infection …

Highlights•Viral conserved domains are often concealed from the humoral
responses.•Memory B cells counteract with viral mutations by germline-encoded cross …

Memory B cells (MBCs) are critical for the rapid development of protective immunity
following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such …

Barrier tissues are the primary site of infection for pathogens likely to cause future
pandemics. Tissue-resident lymphocytes can rapidly detect pathogens upon infection of …

Memory B cells are a key cellular component of the protective humoral responses to
infectious pathogens. Most of our knowledge of memory B-cell responses comes from …

The overarching logos of mammalian memory B cells (MBCs) is to cache the potential for
enhanced antibody production upon secondary exposure to cognate antigenic …

The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …