ADAP is a hematopoietic-restricted adapter protein that promotes integrin activation and is a
carrier for other adapter proteins, Src kinase–associated phosphoprotein 1 (SKAP1) and …

Adhesion and degranulation promoting adapter protein (ADAP) is a multifunctional
hematopoietic adapter protein that regulates TCR-dependent increases in both integrin …

Tight regulation of integrin affinity is critical for hemostasis. A final step of integrin activation
is talin binding to 2 sites within the integrin β cytoplasmic domain. Binding of talin to a …

Platelet aggregation requires agonist-induced αIIbβ3 activation, a process mediated by
Rap1 and talin. To study mechanisms, we engineered αIIbβ3 Chinese hamster ovary (CHO) …

Platelet aggregation is not only an essential part of hemostasis, but also initiates acute
coronary syndrome or ischemic stroke. The precise understanding of the activation …

Integrin adhesion receptors mediate the adhesion of blood cells, such as leukocytes, to
other cells, such as endothelial cells. Integrins also are critical for anchorage of …

Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effective
activation of integrin αIIbβ3 and resulting high-affinity ligand binding in platelets. However …

The adhesion and degranulation-promoting adapter protein (ADAP) is expressed in T cells,
NK cells, myeloid cells, and platelets. The involvement of ADAP in the regulation of receptor …

Platelet adhesion and aggregation at sites of vascular injury are essential for normal
hemostasis but may also lead to pathological thrombus formation, causing diseases such as …

Platelet aggregation at sites of vascular injury is essential for hemostasis but also
thrombosis. Platelet adhesiveness is critically dependent on agonist-induced inside-out …