So little source, so much sink: requirements for afterdepolarizations to propagate in tissue
How early (EADs) and delayed afterdepolarizations (DADs) overcome electrotonic source-
sink mismatches in tissue to trigger premature ventricular complexes remains incompletely …
sink mismatches in tissue to trigger premature ventricular complexes remains incompletely …
Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue
Background Delayed afterdepolarizations (DADs) have been well characterized as
arrhythmia triggers, but their role in generating a tissue substrate vulnerable to reentry is not …
arrhythmia triggers, but their role in generating a tissue substrate vulnerable to reentry is not …
Irregularly appearing early afterdepolarizations in cardiac myocytes: random fluctuations or dynamical chaos?
Irregularly occurring early afterdepolarizations (EADs) in cardiac myocytes are traditionally
hypothesized to be caused by random ion channel fluctuations. In this study, we combined …
hypothesized to be caused by random ion channel fluctuations. In this study, we combined …
Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias
The synchronization of coupled oscillators plays an important role in many biological
systems, including the heart. In heart diseases, cardiac myocytes can exhibit abnormal …
systems, including the heart. In heart diseases, cardiac myocytes can exhibit abnormal …
Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve
Early afterdepolarizations (EADs) are secondary voltage depolarizations during the
repolarizing phase of the action potential, which can cause lethal cardiac arrhythmias. The …
repolarizing phase of the action potential, which can cause lethal cardiac arrhythmias. The …
Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence
J Zeng, Y Rudy - Biophysical journal, 1995 - cell.com
A model of the cardiac ventricular action potential that accounts for dynamic changes in ionic
concentrations was used to study the mechanism, characteristics, and rate dependence of …
concentrations was used to study the mechanism, characteristics, and rate dependence of …
Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?
Z Zhao, H Wen, N Fefelova, C Allen… - American Journal …, 2012 - journals.physiology.org
Early afterdepolarizations (EADs) have been implicated in severe cardiac arrhythmias and
sudden cardiac deaths. However, the mechanism (s) for EAD genesis, especially regarding …
sudden cardiac deaths. However, the mechanism (s) for EAD genesis, especially regarding …
Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes
Early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs) are voltage
oscillations known to cause cardiac arrhythmias. EADs are mainly driven by voltage …
oscillations known to cause cardiac arrhythmias. EADs are mainly driven by voltage …
[HTML][HTML] Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve
Aims Acute ischemia is a major cause of sudden arrhythmic death, further promoted by
potassium current blockers. Macro-reentry around the ischemic region and early …
potassium current blockers. Macro-reentry around the ischemic region and early …
Early afterdepolarizations and cardiac arrhythmias
Early afterdepolarizations (EADs) are an important cause of lethal ventricular arrhythmias in
long QT syndromes and heart failure, but the mechanisms by which EADs at the cellular …
long QT syndromes and heart failure, but the mechanisms by which EADs at the cellular …