Epigenomic and enhancer dysregulation in uterine leiomyomas
OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …
most common benign gynecological tumors and are found in women of reproductive and …
The mechanism and function of epigenetics in uterine leiomyoma development
Uterine leiomyomas, also known as uterine fibroids, are the most common pelvic tumors,
occurring in nearly 70% of all reproductive-aged women and are the leading indication for …
occurring in nearly 70% of all reproductive-aged women and are the leading indication for …
The epidemiology and genetics of uterine leiomyoma
AK Styer, BR Rueda - Best practice & research Clinical obstetrics & …, 2016 - Elsevier
Highlights•Race/ethnicity is the most consistent factor associated with fibroid
development.•Direct cause of genetics and the genesis of fibroids remain uncertain.•Models …
development.•Direct cause of genetics and the genesis of fibroids remain uncertain.•Models …
Molecular and cellular insights into the development of uterine fibroids
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …
Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth
AE Commandeur, AK Styer… - Human Reproduction …, 2015 - academic.oup.com
BACKGROUND Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle
tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas …
tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas …
Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells
NH Khan, R McNally, JJ Kim… - Molecular human …, 2024 - academic.oup.com
Uterine leiomyoma (LM), also known as uterine fibroids, are common gynecological tumors
and can reach a prevalence of 70% among women by the age of 50 years. Notably, the LM …
and can reach a prevalence of 70% among women by the age of 50 years. Notably, the LM …
Gene variants polymorphisms and uterine leiomyoma: an updated review
S Upadhyay, PK Dubey - Frontiers in Genetics, 2024 - frontiersin.org
Uterine leiomyoma, commonly referred to as fibroids, is a benign tumor that develops in the
muscular wall of the uterus. These growths are non-cancerous and can vary in size, ranging …
muscular wall of the uterus. These growths are non-cancerous and can vary in size, ranging …
Molecular differential diagnosis of uterine leiomyomas and leiomyosarcomas
Uterine leiomyomas (LM) and leiomyosarcomas (LMS) are considered biologically
unrelated tumors due to their cytogenetic and molecular disparity. Yet, these tumors share …
unrelated tumors due to their cytogenetic and molecular disparity. Yet, these tumors share …
Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: new evidence and a systematic review
AA Arslan, LI Gold, K Mittal, TC Suen… - Human …, 2005 - academic.oup.com
BACKGROUND: Uterine leiomyomas are extremely common and a major cause of pelvic
pain, bleeding, infertility, and the leading indication for hysterectomy. Familial and …
pain, bleeding, infertility, and the leading indication for hysterectomy. Familial and …
Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma
Background Uterine leiomyomas, or fibroids, represent the most common benign tumor of
the female reproductive tract. Fibroids become symptomatic in 30% of all women and up to …
the female reproductive tract. Fibroids become symptomatic in 30% of all women and up to …