Epigenomic and enhancer dysregulation in uterine leiomyomas

OW Mlodawska, P Saini, JB Parker… - Human …, 2022 - academic.oup.com
BACKGROUND Uterine leiomyomas, also known as uterine fibroids or myomas, are the
most common benign gynecological tumors and are found in women of reproductive and …

The mechanism and function of epigenetics in uterine leiomyoma development

Q Yang, A Mas, MP Diamond… - Reproductive …, 2016 - journals.sagepub.com
Uterine leiomyomas, also known as uterine fibroids, are the most common pelvic tumors,
occurring in nearly 70% of all reproductive-aged women and are the leading indication for …

The epidemiology and genetics of uterine leiomyoma

AK Styer, BR Rueda - Best practice & research Clinical obstetrics & …, 2016 - Elsevier
Highlights•Race/ethnicity is the most consistent factor associated with fibroid
development.•Direct cause of genetics and the genesis of fibroids remain uncertain.•Models …

Molecular and cellular insights into the development of uterine fibroids

A Machado-Lopez, C Simón, A Mas - International journal of molecular …, 2021 - mdpi.com
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth

AE Commandeur, AK Styer… - Human Reproduction …, 2015 - academic.oup.com
BACKGROUND Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle
tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas …

Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells

NH Khan, R McNally, JJ Kim… - Molecular human …, 2024 - academic.oup.com
Uterine leiomyoma (LM), also known as uterine fibroids, are common gynecological tumors
and can reach a prevalence of 70% among women by the age of 50 years. Notably, the LM …

Gene variants polymorphisms and uterine leiomyoma: an updated review

S Upadhyay, PK Dubey - Frontiers in Genetics, 2024 - frontiersin.org
Uterine leiomyoma, commonly referred to as fibroids, is a benign tumor that develops in the
muscular wall of the uterus. These growths are non-cancerous and can vary in size, ranging …

Molecular differential diagnosis of uterine leiomyomas and leiomyosarcomas

A Mas, C Simón - Biology of Reproduction, 2019 - academic.oup.com
Uterine leiomyomas (LM) and leiomyosarcomas (LMS) are considered biologically
unrelated tumors due to their cytogenetic and molecular disparity. Yet, these tumors share …

Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: new evidence and a systematic review

AA Arslan, LI Gold, K Mittal, TC Suen… - Human …, 2005 - academic.oup.com
BACKGROUND: Uterine leiomyomas are extremely common and a major cause of pelvic
pain, bleeding, infertility, and the leading indication for hysterectomy. Familial and …

Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma

A Navarro, P Yin, D Monsivais, SM Lin, P Du, JJ Wei… - PloS one, 2012 - journals.plos.org
Background Uterine leiomyomas, or fibroids, represent the most common benign tumor of
the female reproductive tract. Fibroids become symptomatic in 30% of all women and up to …