Context: Progestin-only pills, the main hormonal alternative to ethinyl estradiol-containing
pills in women bearing vascular risk factors, are poorly tolerated due to irregular bleeding. In …

OBJECTIVE: To test potential contraceptive mechanisms of the selective P receptor
modulator CDB-2914 in the early luteal phase. DESIGN: Prospective randomized clinical …

The impact of the antiprogesterone RU486 [17 β hydroxy-11 β-(4-dimethylaminophenyl) 17
α-(1-propynyl) estra-4, 9-dien-3-one] on the hypothalamic-pituitary-ovarian-endometrial axis …

Objective To examine hormonal and endometrial responses to intermittent low-dose RU486
administration in the luteal phase of the menstrual cycle. Design Prospective open trial in …

Progesterone receptors (PR) mediate multiple aspects of female reproduction and are
important targets for reagents that can modulate progesterone-dependent events. Many …

Dienogest (DNG) is a 19-nortestosterone derivative (a C-19 progestogen) with a
cyanomethyl instead of an ethinyl group at the C-17 position, which may make the …

STUDY QUESTION Does administration of vilaprisan (VPR) to healthy women for 12 weeks
reduce menstrual bleeding? SUMMARY ANSWER In this 12-week proof-of-concept phase 1 …

Org 31710 and Org 33628 are two highly selective progesterone receptor modulators
(PRMs) with respect to their anti-progestational and anti-glucocorticoid activity. The …

OBJECTIVE: To evaluate efficacy, endometrial safety, and overall safety of a single-capsule
17β-estradiol–progesterone (TX-001HR) for treating menopausal moderate-to-severe …

A large number of estrogen/progestogen preparations are available for the treatment of
estrogen-deficiency symptoms. These preparations differ in the route of administration, the …