ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …

The Hippo pathway, initially identified through screenings for mutant tumor suppressors in
Drosophila, is an evolutionarily conserved signaling pathway that controls organ size by …

Highlights•YAP/TAZ are activated in a broad number of solid tumors.•YAP/TAZ instrumental
for tumor initiation, growth, metastasis and chemoresistance.•Several inputs control …

YAP and TAZ are ubiquitously expressed homologous proteins originally identified as
penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

When properly employed, targeted therapies are effective cancer treatments. However, the
development of such therapies requires the identification of targetable drivers of cancer …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …