The ideal nonviral vector delivers its nucleic acid cargo to a specific intracellular target.
Vectors enter cells mainly through endocytosis and are distributed to various intracellular …

Endocytosis is the process by which cells take up macromolecules from the surrounding
medium. The best-characterized process is the so-called clathrin-dependent endocytosis …

Cationic lipids are exploited as vectors ('lipoplexes') for delivering nucleic acids, including
genes, into cells for both therapeutic and cell biological purposes. However, to meet …

Non-viral gene delivery is currently a hot subject for its relative safety and simplicity of use;
however, it is still far from being ideal enough to be clinically used for its comparatively lower …

This theme issue, edited by Hamm-Alvarez and Okamoto (University of Southern California),
brings together a collection of articles authored by experts working in the areas of …

Most in vivo gene therapies will require cell-specific targeting. Although vector targeting
through ligand attachment has met with success in generating gene delivery particles that …

Non-viral vector mediated gene transfer, compared to viral vector mediated one, is a
promising tool for the safe delivery of therapeutic DNA in genetic and acquired human …

Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …

Plasmid DNA, naked or bound to a non-viral vector, is taken up by endocytosis. As a result, it
has to travel through the intracellular endocytic pathway involving endosomes and …

Conspectus Over the past decades, major efforts were undertaken to develop devices on a
nanoscale level for the efficient and nontoxic delivery of molecules to tissues and cells, for …