Droplet probe: coupling chromatography to the in situ evaluation of the chemistry of nature

NH Oberlies, SL Knowles, CSM Amrine, D Kao… - Natural product …, 2019 - pubs.rsc.org
Covering: up to 2019 The chemistry of nature can be beautiful, inspiring, beneficial and
poisonous, depending on perspective. Since the isolation of the first secondary metabolites …

Dereplicating and Spatial Mapping of Secondary Metabolites from Fungal Cultures in Situ

VP Sica, HA Raja, T El-Elimat, V Kertesz… - Journal of Natural …, 2015 - ACS Publications
Ambient ionization mass spectrometry techniques have recently become prevalent in natural
product research due to their ability to examine secondary metabolites in situ. These …

Sampling reliability, spatial resolution, spatial precision, and extraction efficiency in droplet‐based liquid microjunction surface sampling

V Kertesz, GJ Van Berkel - Rapid Communications in Mass …, 2014 - Wiley Online Library
RATIONALE Droplet‐based liquid extraction approaches for spatially resolved surface
sampling coupled with high‐performance liquid chromatography/mass spectrometry …

High-Throughput Nanoliter Sampling and Direct Analysis of Biological Fluids Using Droplet Imbibition Mass Spectrometry

T Sahraeian, E Amoah, DS Kulyk… - Analytical …, 2023 - ACS Publications
A high-throughput droplet imbibition mass spectrometry (MS) experiment is reported for the
first time that allows direct analysis of ultra-small volumes of complex mixtures. In this …

Re‐Imagining Drug Discovery using Mass Spectrometry

RG Cooks, Y Feng, KH Huang… - Israel journal of …, 2023 - Wiley Online Library
It is argued that each of the three key steps in drug discovery,(i) reaction screening to find
successful routes to desired drug candidates,(ii) scale up of the synthesis to produce …

An enhanced droplet-based liquid microjunction surface sampling system coupled with HPLC-ESI-MS/MS for spatially resolved analysis

V Kertesz, TM Weiskittel, GJ Van Berkel - Analytical and bioanalytical …, 2015 - Springer
Droplet-based liquid microjunction surface sampling coupled with high-performance liquid
chromatography (HPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) …

The liquid micro junction-surface sampling probe (LMJ-SSP); a versatile ambient mass spectrometry interface

D Simon, R Oleschuk - Analyst, 2021 - pubs.rsc.org
Ambient ionization methods have become important tools in mass spectrometry. The LMJ-
SSP can significantly simplify/reduce lengthy sample preparation requirements associated …

Mass spectrometry of natural products: current, emerging and future technologies

A Bouslimani, LM Sanchez, N Garg… - Natural product …, 2014 - pubs.rsc.org
Although mass spectrometry is a century old technology, we are entering into an exciting
time for the analysis of molecular information directly from complex biological systems. In …

From structural determination of natural products in complex mixtures to single cell resolution: Perspectives on advances and challenges for mass spectrometry

NP Lopes, R Roberto da Silva - Frontiers in Natural Products, 2023 - frontiersin.org
The search for new Natural Products is one of the oldest interests for research in chemistry.
The history of this discipline is very prolific, from its initial uses as medicine to advanced …

Mass spectrometry of small molecules and natural products

PC Dorrestein - Natural Product Reports, 2014 - pubs.rsc.org
The molecular characterization of our natural world with mass spectrometry is at a pivotal
and exciting stage. We are at the start of major transformations that are going to take place in …